Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies
<b>Background</b>: Brain cancers represent a formidable oncological challenge characterized by their aggressive nature and resistance to conventional therapeutic interventions. The tumor microenvironment has emerged as a critical determinant of tumor progression and treatment efficacy. W...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/216 |
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| author | Min-Hee Yi Jinkyung Lee Subin Moon EunA So Geonhyeok Bang Kyung-Sub Moon Kyung-Hwa Lee |
| author_facet | Min-Hee Yi Jinkyung Lee Subin Moon EunA So Geonhyeok Bang Kyung-Sub Moon Kyung-Hwa Lee |
| author_sort | Min-Hee Yi |
| collection | DOAJ |
| description | <b>Background</b>: Brain cancers represent a formidable oncological challenge characterized by their aggressive nature and resistance to conventional therapeutic interventions. The tumor microenvironment has emerged as a critical determinant of tumor progression and treatment efficacy. Within this complex ecosystem, microglia and macrophages play fundamental roles, forming intricate networks with peripheral immune cell populations, particularly T cells. The precise mechanisms underlying microglial interactions with T cells and their contributions to immunosuppression remain incompletely understood. <b>Methods</b>: This review comprehensively examines the complex cellular dialogue between microglia and T cells in two prominent brain malignancies: primary glioblastoma and secondary brain metastases. <b>Results</b>: Through a comprehensive review of the current scientific literature, we explore the nuanced mechanisms through which microglial-T cell interactions modulate tumor growth and immune responses. <b>Conclusions</b>: Our analysis seeks to unravel the cellular communication pathways that potentially underpin tumor progression, with the ultimate goal of illuminating novel therapeutic strategies for brain cancer intervention. |
| format | Article |
| id | doaj-art-3aa63b49091444dbbca09927d8a8ef2a |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-3aa63b49091444dbbca09927d8a8ef2a2025-01-24T13:24:26ZengMDPI AGBiomedicines2227-90592025-01-0113121610.3390/biomedicines13010216Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic StrategiesMin-Hee Yi0Jinkyung Lee1Subin Moon2EunA So3Geonhyeok Bang4Kyung-Sub Moon5Kyung-Hwa Lee6Department of Microbiology and Immunology, Chonnam National University Medical School, Hwasun 58128, Jeollanam-do, Republic of KoreaBiomedical Sciences Graduate Program (BMSGP), Chonnam National University, Hwasun 58128, Jeollanam-do, Republic of KoreaDepartment of Medicine, College of Medicine, Chosun University, Gwangju 61452, Republic of KoreaBiomedical Sciences Graduate Program (BMSGP), Chonnam National University, Hwasun 58128, Jeollanam-do, Republic of KoreaDepartment of Microbiology and Immunology, Chonnam National University Medical School, Hwasun 58128, Jeollanam-do, Republic of KoreaDepartment of Neurosurgery, Chonnam National University Hwasun Hospital, Hwasun 58128, Jeollanam-do, Republic of KoreaBiomedical Sciences Graduate Program (BMSGP), Chonnam National University, Hwasun 58128, Jeollanam-do, Republic of Korea<b>Background</b>: Brain cancers represent a formidable oncological challenge characterized by their aggressive nature and resistance to conventional therapeutic interventions. The tumor microenvironment has emerged as a critical determinant of tumor progression and treatment efficacy. Within this complex ecosystem, microglia and macrophages play fundamental roles, forming intricate networks with peripheral immune cell populations, particularly T cells. The precise mechanisms underlying microglial interactions with T cells and their contributions to immunosuppression remain incompletely understood. <b>Methods</b>: This review comprehensively examines the complex cellular dialogue between microglia and T cells in two prominent brain malignancies: primary glioblastoma and secondary brain metastases. <b>Results</b>: Through a comprehensive review of the current scientific literature, we explore the nuanced mechanisms through which microglial-T cell interactions modulate tumor growth and immune responses. <b>Conclusions</b>: Our analysis seeks to unravel the cellular communication pathways that potentially underpin tumor progression, with the ultimate goal of illuminating novel therapeutic strategies for brain cancer intervention.https://www.mdpi.com/2227-9059/13/1/216brain metastasisglioblastomatumor-associated microgliatumor-infiltrating T cellstumor microenvironment |
| spellingShingle | Min-Hee Yi Jinkyung Lee Subin Moon EunA So Geonhyeok Bang Kyung-Sub Moon Kyung-Hwa Lee Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies Biomedicines brain metastasis glioblastoma tumor-associated microglia tumor-infiltrating T cells tumor microenvironment |
| title | Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies |
| title_full | Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies |
| title_fullStr | Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies |
| title_full_unstemmed | Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies |
| title_short | Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies |
| title_sort | divergent crosstalk between microglia and t cells in brain cancers implications for novel therapeutic strategies |
| topic | brain metastasis glioblastoma tumor-associated microglia tumor-infiltrating T cells tumor microenvironment |
| url | https://www.mdpi.com/2227-9059/13/1/216 |
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