Evaluating wound-healing effect of silicon-zinc-boron-containing glycerohydrogel and its effect on mammary glands of high producing dairy cows
Cow’s milk quality, which may deteriorate due to inflammatory processes in the mammary glands, remains one of the important problems of dairy farming and requires effective, safe and affordable therapeutic agents. Nanocomposite silicon-zinc-boron-containing glycerohydrogel (Si-Zn-B-gel) may become a ve...
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| Language: | English |
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Da Vinci Media
2023-12-01
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| Series: | Ветеринария сегодня |
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| Online Access: | https://veterinary.arriah.ru/jour/article/view/768 |
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| author | L. I. Drozdova A. S. Barkova M. N. Isakova L. P. Larionov V. V. Permikin N. M. Starikov T. G. Khonina |
| author_facet | L. I. Drozdova A. S. Barkova M. N. Isakova L. P. Larionov V. V. Permikin N. M. Starikov T. G. Khonina |
| author_sort | L. I. Drozdova |
| collection | DOAJ |
| description | Cow’s milk quality, which may deteriorate due to inflammatory processes in the mammary glands, remains one of the important problems of dairy farming and requires effective, safe and affordable therapeutic agents. Nanocomposite silicon-zinc-boron-containing glycerohydrogel (Si-Zn-B-gel) may become a very good solution to the issue. The paper demonstrates wound-healing effect of the glycerohydrogel and confirms its effectiveness for teat hyperkeratosis treatment indairy cows. Results of a rat burn model – based experiment suggest that Si-Zn-B-gel is a promising wound healing agent for topical use. Thus, on Day 9 complete re-epithelialization of the burn surface was observed, with fibrous structures prevailing in the granulation tissue of the dermal layer, on Day 19 a mature scar was formed with a longitudinal alignment of collagen fibers. The production tests conducted inhigh producing dairy cows have demonstrated good therapeutic effect of the Si-Zn-B gel for teat-end hyperkeratosis and confirmed its long-term effect that helps to longer maintain the results achieved during treatment. After a 7-day treatment physiological structure of up to 27.8% teats improved, on Day 14 of the experiment no severe hyperkeratotic lesions were observed and the number of teats that correspond to the physiological norm was 72.2%. Analysis of the data collected shows that the Si-Zn-B-gel is effective for teat-end hyperkeratosis treatment, thus, it prevents mastitis in animals and improves the milk quality. |
| format | Article |
| id | doaj-art-3a8f64274a854e829bfec74e7e450692 |
| institution | Kabale University |
| issn | 2304-196X 2658-6959 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Da Vinci Media |
| record_format | Article |
| series | Ветеринария сегодня |
| spelling | doaj-art-3a8f64274a854e829bfec74e7e4506922025-02-06T09:52:10ZengDa Vinci MediaВетеринария сегодня2304-196X2658-69592023-12-0112432233010.29326/2304-196X-2023-12-4-322-330639Evaluating wound-healing effect of silicon-zinc-boron-containing glycerohydrogel and its effect on mammary glands of high producing dairy cowsL. I. Drozdova0A. S. Barkova1M. N. Isakova2L. P. Larionov3V. V. Permikin4N. M. Starikov5T. G. Khonina6FSBEI HE “Ural State Agrarian University” (FSBEI HE Ural SAU)FSBEI HE “Kaliningrad State Technical University” (FSBEI HE “KSTU”)FSBSI “Ural Federal Agrarian Scientific Research Centre, Ural Branch of the Russian Academy of Sciences” (FSBSI UrFASRC, UrB of RAS)FSBI HPE “Ural State Medical University” of the Ministry of Healthcare of the Russian Federation (FSBI НРE “USMU” MOH Russia)I. Ya. Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences (IOS UB RAS)FSBSI “Ural Federal Agrarian Scientific Research Centre, Ural Branch of the Russian Academy of Sciences” (FSBSI UrFASRC, UrB of RAS)FSBEI HE “Ural State Agrarian University” (FSBEI HE Ural SAU); I. Ya. Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences (IOS UB RAS)Cow’s milk quality, which may deteriorate due to inflammatory processes in the mammary glands, remains one of the important problems of dairy farming and requires effective, safe and affordable therapeutic agents. Nanocomposite silicon-zinc-boron-containing glycerohydrogel (Si-Zn-B-gel) may become a very good solution to the issue. The paper demonstrates wound-healing effect of the glycerohydrogel and confirms its effectiveness for teat hyperkeratosis treatment indairy cows. Results of a rat burn model – based experiment suggest that Si-Zn-B-gel is a promising wound healing agent for topical use. Thus, on Day 9 complete re-epithelialization of the burn surface was observed, with fibrous structures prevailing in the granulation tissue of the dermal layer, on Day 19 a mature scar was formed with a longitudinal alignment of collagen fibers. The production tests conducted inhigh producing dairy cows have demonstrated good therapeutic effect of the Si-Zn-B gel for teat-end hyperkeratosis and confirmed its long-term effect that helps to longer maintain the results achieved during treatment. After a 7-day treatment physiological structure of up to 27.8% teats improved, on Day 14 of the experiment no severe hyperkeratotic lesions were observed and the number of teats that correspond to the physiological norm was 72.2%. Analysis of the data collected shows that the Si-Zn-B-gel is effective for teat-end hyperkeratosis treatment, thus, it prevents mastitis in animals and improves the milk quality.https://veterinary.arriah.ru/jour/article/view/768silicon-zinc-boron-containing glycerohydrogel10% methyluracyl ointmentwound healing effectlong-term effecthigh producing dairy cowsmammary glandsmastitisteat-end hyperkeratosismilk quality |
| spellingShingle | L. I. Drozdova A. S. Barkova M. N. Isakova L. P. Larionov V. V. Permikin N. M. Starikov T. G. Khonina Evaluating wound-healing effect of silicon-zinc-boron-containing glycerohydrogel and its effect on mammary glands of high producing dairy cows Ветеринария сегодня silicon-zinc-boron-containing glycerohydrogel 10% methyluracyl ointment wound healing effect long-term effect high producing dairy cows mammary glands mastitis teat-end hyperkeratosis milk quality |
| title | Evaluating wound-healing effect of silicon-zinc-boron-containing glycerohydrogel and its effect on mammary glands of high producing dairy cows |
| title_full | Evaluating wound-healing effect of silicon-zinc-boron-containing glycerohydrogel and its effect on mammary glands of high producing dairy cows |
| title_fullStr | Evaluating wound-healing effect of silicon-zinc-boron-containing glycerohydrogel and its effect on mammary glands of high producing dairy cows |
| title_full_unstemmed | Evaluating wound-healing effect of silicon-zinc-boron-containing glycerohydrogel and its effect on mammary glands of high producing dairy cows |
| title_short | Evaluating wound-healing effect of silicon-zinc-boron-containing glycerohydrogel and its effect on mammary glands of high producing dairy cows |
| title_sort | evaluating wound healing effect of silicon zinc boron containing glycerohydrogel and its effect on mammary glands of high producing dairy cows |
| topic | silicon-zinc-boron-containing glycerohydrogel 10% methyluracyl ointment wound healing effect long-term effect high producing dairy cows mammary glands mastitis teat-end hyperkeratosis milk quality |
| url | https://veterinary.arriah.ru/jour/article/view/768 |
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