Humoral correlates of protection against Mycobacterium tuberculosis following intravenous BCG vaccination in rhesus macaques

Humoral correlates of protection against Mycobacterium tuberculosis following intravenous BCG vaccination in rhesus macaques

Summary: Altering Bacille Calmette-Guérin (BCG) immunization from low-dose intradermal (i.d.) to high-dose intravenous (i.v.) vaccination provides a high level of protection against Mycobacterium tuberculosis (Mtb). In addition to strong T cell immunity, i.v. BCG drives robust humoral immune respons...

Full description

Saved in:

Bibliographic Details
Main Authors:	Edward B. Irvine, Patricia A. Darrah, Shu Wang, Chuangqi Wang, Ryan P. McNamara, Mario Roederer, Robert A. Seder, Douglas A. Lauffenburger, JoAnne L. Flynn, Sarah M. Fortune, Galit Alter
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Series:	iScience
Subjects:	Health sciences Immunology Pathophysiology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224023538
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Effectiveness of islatravir post‐exposure prophylaxis after intravenous challenge with simian immunodeficiency virus in rhesus macaques
by: Martin Markowitz, et al.
Published: (2025-06-01)

The ocular surface microbiome of rhesus macaques
by: Joelle K. Hass, et al.
Published: (2025-08-01)

Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques
by: Payal P. Pratap, et al.
Published: (2025-08-01)

Comparison of sensitivity of rhesus and cynomolgus macaque for acute radiation effects
by: Vijay K. Singh, et al.
Published: (2025-07-01)

MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques.
by: Frank A W Verreck, et al.
Published: (2009-01-01)

Developing a Virtual Model of the Rhesus Macaque Inner Ear
by: Cayman Matson, et al.
Published: (2024-11-01)

Diversity of Campylobacter species in a rhesus macaque breeding colony
by: Irving Nachamkin
Published: (2025-04-01)

Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques.
by: Lark L Coffey, et al.
Published: (2017-01-01)

Safety of Bioplasma FDP and Hemopure in rhesus macaques after 30% hemorrhage
by: Lee A Wallis, et al.
Published: (2024-01-01)

A Study of Spontaneous Self-Injurious Behavior and Neuroimaging in Rhesus Macaques
by: Ya-Li Zhang, et al.
Published: (2025-01-01)

Delayed imitation of lipsmacking gestures by infant rhesus macaques (Macaca mulatta).
by: Annika Paukner, et al.
Published: (2011-01-01)

Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques.
by: Michael K McCracken, et al.
Published: (2017-08-01)

The use of preferred social stimuli as rewards for rhesus macaques in behavioural neuroscience.
by: Helen Gray, et al.
Published: (2017-01-01)

Combining a rhesus cytomegalovirus/SIV vaccine with a neutralizing antibody to protect against SIV challenges in rhesus macaques
by: Jessica Coppola, et al.
Published: (2025-06-01)

Is there a role for oxidative stress and mitochondrial dysfunction in age-associated bladder disorders?
by: Lori A Birder
Published: (2020-01-01)

DNA encoding an HIV-1 Gag/human lysosome-associated membrane protein-1 chimera elicits a broad cellular and humoral immune response in Rhesus macaques.
by: Priya Chikhlikar, et al.
Published: (2006-12-01)

The single-cell transcription reveals the aberrant differentiation trajectory of chondrocytes in the intervertebral disc for congenital scoliosis
by: Junfeng Wang, et al.
Published: (2025-06-01)

Reduction of intestinal RIPK1 ameliorates HFD-induced metabolic disorders in female mice
by: Ye Yuan, et al.
Published: (2025-02-01)

Expression patterns of blood-based biomarkers of neurodegeneration and inflammation across adulthood in rhesus macaques
by: Ludwig A.P. Metzler, et al.
Published: (2025-05-01)

AI for rapid identification of major butyrate-producing bacteria in rhesus macaques (Macaca mulatta)
by: Annemiek Maaskant, et al.
Published: (2025-04-01)

Comparative analysis of sex-dependent serum metabolomic patterns across the lifespan of rhesus macaques
by: Ludwig A. P. Metzler, et al.
Published: (2025-08-01)

Vocal membranes lower the phonation threshold pressure in rhesus macaques (Macaca mulatta)
by: Mayuka Kanaya, et al.
Published: (2025-06-01)

Novel rhesus macaque immunoglobulin germline genes identified by three sequencing approaches
by: Yicheng Guo, et al.
Published: (2024-12-01)

Reply to Nachamkin, “Diversity of Campylobacter species in a rhesus macaque breeding colony”
by: Rebecca L. Bacon, et al.
Published: (2025-04-01)

Vitrification of Rhesus Macaque Mesenchymal Stem Cells and the Effects on Global Gene Expression
by: Xufeng Fu, et al.
Published: (2017-01-01)

RhCMV reactivation in SARS-CoV-2 infected aged rhesus macaques
by: Jamin W. Roh, et al.
Published: (2025-06-01)

Targeting insulin-like growth factor 1 receptor restricts development and severity of secondary lymphedema in mice
by: Yinan Yuan, et al.
Published: (2025-03-01)

Modifications to rhesus macaque TCR constant regions improve TCR cell surface expression.
by: Lori V Coren, et al.
Published: (2025-01-01)

Medial prefrontal glutamate response to acute stress is associated with social subordination in female rhesus macaques
by: Michael T. Treadway, et al.
Published: (2025-03-01)

Hypomelanosis of Ito: description of the clinical case
by: M. L. Kosheleva, et al.
Published: (2023-12-01)

Pulmonary lymphoid tissue induced after SARS-CoV-2 infection in rhesus macaques
by: Zhong-Min Ma, et al.
Published: (2025-03-01)

Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model
by: Hannah K. Jaeger, et al.
Published: (2025-05-01)

Ranking network of a captive rhesus macaque society: a sophisticated corporative kingdom.
by: Hsieh Fushing, et al.
Published: (2011-03-01)

Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques
by: Brett D. Story, et al.
Published: (2025-12-01)

Pathogenesis of peritoneal high‐grade serous carcinoma after risk‐reducing surgery: a systematic review
by: Tamar A Gootzen, et al.
Published: (2025-07-01)

Interferon-gamma rescues dendritic cell calcineurin-dependent responses to Aspergillus fumigatus via Stat3 to Stat1 switching
by: Amit Adlakha, et al.
Published: (2025-02-01)

An enhanced machine learning-based prognostic prediction model for patients with AECOPD on invasive mechanical ventilation
by: Yujie Fu, et al.
Published: (2024-12-01)

Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis
by: Nisha Singh, et al.
Published: (2024-12-01)

Association of antibody and T cell receptor repertoires in Trypanosoma cruzi infected rhesus macaques and host response to infection
by: Rachel M. Clear, et al.
Published: (2025-06-01)

Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques.
by: Sarah J Byrnes, et al.
Published: (2023-03-01)