Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration
The glutathione S-transferases (GSTs) are involved in biotransformation and detoxification of cadmium (Cd). Genetic polymorphisms in these genes may lead to interindividual variation in Cd susceptibility. The objective of this study was to assess the association of GSTs (GSTT1, GSTM1, and GSTP1 Val...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2012/356126 |
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| author | Nitchaphat Khansakorn Waranya Wongwit Prapin Tharnpoophasiam Bunlue Hengprasith Lerson Suwannathon Suwannee Chanprasertyothin Thunyachai Sura Sming Kaojarern Piyamit Sritara Jintana Sirivarasai |
| author_facet | Nitchaphat Khansakorn Waranya Wongwit Prapin Tharnpoophasiam Bunlue Hengprasith Lerson Suwannathon Suwannee Chanprasertyothin Thunyachai Sura Sming Kaojarern Piyamit Sritara Jintana Sirivarasai |
| author_sort | Nitchaphat Khansakorn |
| collection | DOAJ |
| description | The glutathione S-transferases (GSTs) are involved in biotransformation and detoxification of cadmium (Cd). Genetic polymorphisms in these genes may lead to interindividual variation in Cd susceptibility. The objective of this study was to assess the association of GSTs (GSTT1, GSTM1, and GSTP1 Val105Ile) polymorphisms with blood Cd concentrations in a nonoccupationally exposed population. The 370 blood samples were analyzed for Cd concentration and polymorphisms in GSTs genes. Geometric mean of blood Cd among this population was 0.46±0.02 μg/L (with 95% CI; 0.43–0.49 μg/L). Blood Cd concentrations in subjects carrying GSTP1 Val/Val genotype were significantly higher than those with Ile/Ile and Ile/Val genotypes. No significant differences in blood Cd concentrations among individual with gene deletions of GSTT1 and GSTM1 were observed. GSTP1/GSTT1 and GSTP1/GSTM1 combinations showed significantly associated with increase in blood Cd levels. This study indicated that polymorphisms of GSTP1 combined with GSTT1 and/or GSTM1 deletion are likely to influence on individual susceptibility to cadmium toxicity. |
| format | Article |
| id | doaj-art-3a695691f6a74a3a8729f7368b334055 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-3a695691f6a74a3a8729f7368b3340552025-02-03T01:21:23ZengWileyJournal of Toxicology1687-81911687-82052012-01-01201210.1155/2012/356126356126Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium ConcentrationNitchaphat Khansakorn0Waranya Wongwit1Prapin Tharnpoophasiam2Bunlue Hengprasith3Lerson Suwannathon4Suwannee Chanprasertyothin5Thunyachai Sura6Sming Kaojarern7Piyamit Sritara8Jintana Sirivarasai9Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandDepartment of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandDepartment of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandHealth Office, Electricity Generating Authority of Thailand, Nonthaburi 11130, ThailandExcellence Service Center For Medical Technology and Quality Improvement, Faculty of Medical Technology, Mahidol University, Bangkok 10700, ThailandOffice of Research Academic and Innovation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandThe glutathione S-transferases (GSTs) are involved in biotransformation and detoxification of cadmium (Cd). Genetic polymorphisms in these genes may lead to interindividual variation in Cd susceptibility. The objective of this study was to assess the association of GSTs (GSTT1, GSTM1, and GSTP1 Val105Ile) polymorphisms with blood Cd concentrations in a nonoccupationally exposed population. The 370 blood samples were analyzed for Cd concentration and polymorphisms in GSTs genes. Geometric mean of blood Cd among this population was 0.46±0.02 μg/L (with 95% CI; 0.43–0.49 μg/L). Blood Cd concentrations in subjects carrying GSTP1 Val/Val genotype were significantly higher than those with Ile/Ile and Ile/Val genotypes. No significant differences in blood Cd concentrations among individual with gene deletions of GSTT1 and GSTM1 were observed. GSTP1/GSTT1 and GSTP1/GSTM1 combinations showed significantly associated with increase in blood Cd levels. This study indicated that polymorphisms of GSTP1 combined with GSTT1 and/or GSTM1 deletion are likely to influence on individual susceptibility to cadmium toxicity.http://dx.doi.org/10.1155/2012/356126 |
| spellingShingle | Nitchaphat Khansakorn Waranya Wongwit Prapin Tharnpoophasiam Bunlue Hengprasith Lerson Suwannathon Suwannee Chanprasertyothin Thunyachai Sura Sming Kaojarern Piyamit Sritara Jintana Sirivarasai Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration Journal of Toxicology |
| title | Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration |
| title_full | Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration |
| title_fullStr | Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration |
| title_full_unstemmed | Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration |
| title_short | Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration |
| title_sort | genetic variations of glutathione s transferase influence on blood cadmium concentration |
| url | http://dx.doi.org/10.1155/2012/356126 |
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