Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies

Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies

Abstract Polycystic ovary syndrome (PCOS), the most common endocrine disease in women of reproductive age, severely impacts female fertility due to chronic anovulation and currently lacks effective clinical treatment strategies. The extracellular matrix (ECM) is a three-dimensional, non-cellular fra...

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Bibliographic Details
Main Authors: Yunxi Liu, Jialei Zhu, Yingli Yang, Zhengyun Chen, Yong Zhou, Weidong Fei, Xian Zhang, Yongquan Zheng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Biological Engineering
Subjects:
Polycystic ovary syndrome
Extracellular matrix
Follicle development
Pathogenesis
Therapeutic strategies
Online Access:https://doi.org/10.1186/s13036-025-00533-9
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