Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer
The prognosis of epithelial ovarian cancer (EOC), the primary cause of death from gynaecological malignancies, has only modestly improved over the last decades. Immunotherapeutic treatment using a cocktail of antigens has been proposed as a “universal” vaccine strategy. We determined the expression...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/891505 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568061033447424 |
|---|---|
| author | Renee Vermeij Toos Daemen Geertruida H. de Bock Pauline de Graeff Ninke Leffers Annechien Lambeck Klaske A. ten Hoor Harry Hollema Ate G. J. van der Zee Hans W. Nijman |
| author_facet | Renee Vermeij Toos Daemen Geertruida H. de Bock Pauline de Graeff Ninke Leffers Annechien Lambeck Klaske A. ten Hoor Harry Hollema Ate G. J. van der Zee Hans W. Nijman |
| author_sort | Renee Vermeij |
| collection | DOAJ |
| description | The prognosis of epithelial ovarian cancer (EOC), the primary cause of death from gynaecological malignancies, has only modestly improved over the last decades. Immunotherapeutic treatment using a cocktail of antigens has been proposed as a “universal” vaccine strategy. We determined the expression of tumor antigens in the context of MHC class I expression in 270 primary tumor samples using tissue microarray. Expression of tumor antigens p53, SP17, survivin, WT1, and NY-ESO-1 was observed in 120 (48.0%), 173 (68.9%), 208 (90.0%), 129 (56.3%), and 27 (11.0%) of 270 tumor specimens, respectively. In 93.2% of EOC, at least one of the investigated tumor antigens was (over)expressed. Expression of MHC class I was observed in 78.1% of EOC. In 3 out 4 primary tumors, (over)expression of a tumor antigen combined with MHC class I was observed. These results indicate that a multiepitope vaccine, comprising these antigens, could serve as a universal therapeutic vaccine for the vast majority of ovarian cancer patients. |
| format | Article |
| id | doaj-art-3a3d1eab845a458bb2b9a343d0185062 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-3a3d1eab845a458bb2b9a343d01850622025-02-03T00:59:47ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/891505891505Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian CancerRenee Vermeij0Toos Daemen1Geertruida H. de Bock2Pauline de Graeff3Ninke Leffers4Annechien Lambeck5Klaske A. ten Hoor6Harry Hollema7Ate G. J. van der Zee8Hans W. Nijman9Department of Gynecological Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Gynecological Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Gynecological Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Gynecological Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Gynecological Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Gynecological Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Gynecological Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsThe prognosis of epithelial ovarian cancer (EOC), the primary cause of death from gynaecological malignancies, has only modestly improved over the last decades. Immunotherapeutic treatment using a cocktail of antigens has been proposed as a “universal” vaccine strategy. We determined the expression of tumor antigens in the context of MHC class I expression in 270 primary tumor samples using tissue microarray. Expression of tumor antigens p53, SP17, survivin, WT1, and NY-ESO-1 was observed in 120 (48.0%), 173 (68.9%), 208 (90.0%), 129 (56.3%), and 27 (11.0%) of 270 tumor specimens, respectively. In 93.2% of EOC, at least one of the investigated tumor antigens was (over)expressed. Expression of MHC class I was observed in 78.1% of EOC. In 3 out 4 primary tumors, (over)expression of a tumor antigen combined with MHC class I was observed. These results indicate that a multiepitope vaccine, comprising these antigens, could serve as a universal therapeutic vaccine for the vast majority of ovarian cancer patients.http://dx.doi.org/10.1155/2010/891505 |
| spellingShingle | Renee Vermeij Toos Daemen Geertruida H. de Bock Pauline de Graeff Ninke Leffers Annechien Lambeck Klaske A. ten Hoor Harry Hollema Ate G. J. van der Zee Hans W. Nijman Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer Clinical and Developmental Immunology |
| title | Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer |
| title_full | Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer |
| title_fullStr | Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer |
| title_full_unstemmed | Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer |
| title_short | Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer |
| title_sort | potential target antigens for a universal vaccine in epithelial ovarian cancer |
| url | http://dx.doi.org/10.1155/2010/891505 |
| work_keys_str_mv | AT reneevermeij potentialtargetantigensforauniversalvaccineinepithelialovariancancer AT toosdaemen potentialtargetantigensforauniversalvaccineinepithelialovariancancer AT geertruidahdebock potentialtargetantigensforauniversalvaccineinepithelialovariancancer AT paulinedegraeff potentialtargetantigensforauniversalvaccineinepithelialovariancancer AT ninkeleffers potentialtargetantigensforauniversalvaccineinepithelialovariancancer AT annechienlambeck potentialtargetantigensforauniversalvaccineinepithelialovariancancer AT klaskeatenhoor potentialtargetantigensforauniversalvaccineinepithelialovariancancer AT harryhollema potentialtargetantigensforauniversalvaccineinepithelialovariancancer AT ategjvanderzee potentialtargetantigensforauniversalvaccineinepithelialovariancancer AT hanswnijman potentialtargetantigensforauniversalvaccineinepithelialovariancancer |