Metastatic MiT family/TFE translocation renal cell carcinoma in adults: case series reports and literature reviews
This article presents a case study of three patients diagnosed with MiT/TFE tRCC at our hospital. The tumors were located in the left kidney of all three patients, with two of them being under 30 years old. Within a short timeframe, two of all patients developed liver metastases. Genetic testing was...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1501820/full |
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| author | Xueru Sun Hong Wang XiuYue Man Chen Chen XiaoFeng Cong Jing Zhang Lei Yang |
| author_facet | Xueru Sun Hong Wang XiuYue Man Chen Chen XiaoFeng Cong Jing Zhang Lei Yang |
| author_sort | Xueru Sun |
| collection | DOAJ |
| description | This article presents a case study of three patients diagnosed with MiT/TFE tRCC at our hospital. The tumors were located in the left kidney of all three patients, with two of them being under 30 years old. Within a short timeframe, two of all patients developed liver metastases. Genetic testing was conducted in one case, FISH testing in another, and all cases underwent a combination of targeted therapy and immunotherapy. By analyzing the clinical, pathological, and genomic characteristics of these patients, this article aims to enhance the understanding of MiT family translocation renal cell carcinoma, as well as improve the diagnosis, treatment, and prognosis of this rare form of renal cell carcinoma. Further evidence is provided to support these findings. |
| format | Article |
| id | doaj-art-3a3d16d35aa642b092bc959b8d138419 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-3a3d16d35aa642b092bc959b8d1384192025-08-20T03:02:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-03-011510.3389/fonc.2025.15018201501820Metastatic MiT family/TFE translocation renal cell carcinoma in adults: case series reports and literature reviewsXueru SunHong WangXiuYue ManChen ChenXiaoFeng CongJing ZhangLei YangThis article presents a case study of three patients diagnosed with MiT/TFE tRCC at our hospital. The tumors were located in the left kidney of all three patients, with two of them being under 30 years old. Within a short timeframe, two of all patients developed liver metastases. Genetic testing was conducted in one case, FISH testing in another, and all cases underwent a combination of targeted therapy and immunotherapy. By analyzing the clinical, pathological, and genomic characteristics of these patients, this article aims to enhance the understanding of MiT family translocation renal cell carcinoma, as well as improve the diagnosis, treatment, and prognosis of this rare form of renal cell carcinoma. Further evidence is provided to support these findings.https://www.frontiersin.org/articles/10.3389/fonc.2025.1501820/fullMit family translocation renal cell carcinoma (MiT/TFE tRCC)molecular characterizationgenetic mutationbiological behaviortargeted therapyclinical management |
| spellingShingle | Xueru Sun Hong Wang XiuYue Man Chen Chen XiaoFeng Cong Jing Zhang Lei Yang Metastatic MiT family/TFE translocation renal cell carcinoma in adults: case series reports and literature reviews Frontiers in Oncology Mit family translocation renal cell carcinoma (MiT/TFE tRCC) molecular characterization genetic mutation biological behavior targeted therapy clinical management |
| title | Metastatic MiT family/TFE translocation renal cell carcinoma in adults: case series reports and literature reviews |
| title_full | Metastatic MiT family/TFE translocation renal cell carcinoma in adults: case series reports and literature reviews |
| title_fullStr | Metastatic MiT family/TFE translocation renal cell carcinoma in adults: case series reports and literature reviews |
| title_full_unstemmed | Metastatic MiT family/TFE translocation renal cell carcinoma in adults: case series reports and literature reviews |
| title_short | Metastatic MiT family/TFE translocation renal cell carcinoma in adults: case series reports and literature reviews |
| title_sort | metastatic mit family tfe translocation renal cell carcinoma in adults case series reports and literature reviews |
| topic | Mit family translocation renal cell carcinoma (MiT/TFE tRCC) molecular characterization genetic mutation biological behavior targeted therapy clinical management |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1501820/full |
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