Discovery of thymol-fused chalcones as new competitive \(\alpha\)-glucosidase inhibitors: Design, synthesis, biological evaluation, and molecular modeling studies

Discovery of thymol-fused chalcones as new competitive \(\alpha\)-glucosidase inhibitors: Design, synthesis, biological evaluation, and molecular modeling studies

This study aims to synthesize and evaluate the inhibitory activity of thymol derivatives targeting ?-glucosidase using in vitro and in silico studies. Ten thymol derivatives (2-11) including five new thymol-fused chalcones (7-11) were successfully synthesized. Among them, four compounds (4, 8, 9, 11...

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Bibliographic Details
Main Authors: Ade Danova, Elvira Hermawati, Warinthorn Chavasiri, Didin Mujahidin, Anita Alni, Robby Roswanda
Format: Article
Language:English
Published: Komunitas Ilmuwan dan Profesional Muslim Indonesia 2024-12-01
Series:Communications in Science and Technology
Subjects:
thymol
chalcone
diabetes mellitus
molecular docking
molecular dynamics
\(\alpha\)-glucosidase
Online Access:https://cst.kipmi.or.id/journal/article/view/1497
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