Antibody-Mediated Rejection in Kidney Transplantation: A Review
Antibody mediated rejection (AMR) poses a significant and continued challenge for long term graft survival in kidney transplantation. However, in the recent years, there has emerged an increased understanding of the varied manifestations of the antibody mediated processes in kidney transplantation....
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/193724 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565637354881024 |
|---|---|
| author | Chethan Puttarajappa Ron Shapiro Henkie P. Tan |
| author_facet | Chethan Puttarajappa Ron Shapiro Henkie P. Tan |
| author_sort | Chethan Puttarajappa |
| collection | DOAJ |
| description | Antibody mediated rejection (AMR) poses a significant and continued challenge for long term
graft survival in kidney transplantation. However, in the recent years, there has emerged an
increased understanding of the varied manifestations of the antibody mediated processes in
kidney transplantation. In this article, we briefly discuss the various histopathological and clinical
manifestations of AMRs, along with describing the techniques and methods which have made it
easier to define and diagnose these rejections. We also review the emerging issues of C4d
negative AMR, its significance in long term allograft survival and provide a brief summary of the
current management strategies for managing AMRs in kidney transplantation. |
| format | Article |
| id | doaj-art-3a1f7628df0f4319bd488c0088057826 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-3a1f7628df0f4319bd488c00880578262025-02-03T01:07:01ZengWileyJournal of Transplantation2090-00072090-00152012-01-01201210.1155/2012/193724193724Antibody-Mediated Rejection in Kidney Transplantation: A ReviewChethan Puttarajappa0Ron Shapiro1Henkie P. Tan2Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-2582, USADivision of Transplantation, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-2582, USADivision of Transplantation, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-2582, USAAntibody mediated rejection (AMR) poses a significant and continued challenge for long term graft survival in kidney transplantation. However, in the recent years, there has emerged an increased understanding of the varied manifestations of the antibody mediated processes in kidney transplantation. In this article, we briefly discuss the various histopathological and clinical manifestations of AMRs, along with describing the techniques and methods which have made it easier to define and diagnose these rejections. We also review the emerging issues of C4d negative AMR, its significance in long term allograft survival and provide a brief summary of the current management strategies for managing AMRs in kidney transplantation.http://dx.doi.org/10.1155/2012/193724 |
| spellingShingle | Chethan Puttarajappa Ron Shapiro Henkie P. Tan Antibody-Mediated Rejection in Kidney Transplantation: A Review Journal of Transplantation |
| title | Antibody-Mediated Rejection in Kidney Transplantation: A Review |
| title_full | Antibody-Mediated Rejection in Kidney Transplantation: A Review |
| title_fullStr | Antibody-Mediated Rejection in Kidney Transplantation: A Review |
| title_full_unstemmed | Antibody-Mediated Rejection in Kidney Transplantation: A Review |
| title_short | Antibody-Mediated Rejection in Kidney Transplantation: A Review |
| title_sort | antibody mediated rejection in kidney transplantation a review |
| url | http://dx.doi.org/10.1155/2012/193724 |
| work_keys_str_mv | AT chethanputtarajappa antibodymediatedrejectioninkidneytransplantationareview AT ronshapiro antibodymediatedrejectioninkidneytransplantationareview AT henkieptan antibodymediatedrejectioninkidneytransplantationareview |