Astaxanthin mitigates diabetic cardiomyopathy and nephropathy in HF/HFr/STZ diabetic rats via modulating NOX4, fractalkine, Nrf2, and AP-1 pathways

Astaxanthin mitigates diabetic cardiomyopathy and nephropathy in HF/HFr/STZ diabetic rats via modulating NOX4, fractalkine, Nrf2, and AP-1 pathways

Abstract This study investigated the effects of astaxanthin (ASTA) on diabetic cardiomyopathy (DCM) and nephropathy (DN) in rats. Type 2 diabetes was induced through a high-fat/high-fructose (HF/HFr) diet followed by a sub-diabetogenic dose streptozotocin injection. Diabetic rats were treated with A...

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Bibliographic Details
Main Authors: Nesma M.E. Abo El-Nasr, Yosra A. Hussien, Marawan Abd El-Baset, Marwa E. Shabana, Dalia O. Saleh
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Astaxanthin; diabetic cardiomyopathy
Diabetic nephropathy
Oxidative stress
NOX4
Fractalkine
Nrf2
Online Access:https://doi.org/10.1038/s41598-025-06263-8
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