Long-term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosis
Background: Recent data have shown that systemic sclerosis (SSc) is a significant risk factor for coronary artery disease (CAD) and poorer cardiovascular outcomes in the setting of acute coronary syndrome. However, the morphological characteristics of CAD and the long-term cardiovascular outcomes in...
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Elsevier
2025-04-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906725000284 |
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| author | Kazutoshi Hirose Hiroyuki Kiriyama Shun Minatsuki Yugo Nagae Tatsuki Furusawa Takashi Hiruma Atsushi Kobayashi Masataka Sato Shinnosuke Sawano Tatsuya Kamon Hiroki Shinohara Mizuki Miura Akihito Saito Satoshi Kodera Junichi Ishida Norifumi Takeda Hiroyuki Morita Issei Komuro Norihiko Takeda |
| author_facet | Kazutoshi Hirose Hiroyuki Kiriyama Shun Minatsuki Yugo Nagae Tatsuki Furusawa Takashi Hiruma Atsushi Kobayashi Masataka Sato Shinnosuke Sawano Tatsuya Kamon Hiroki Shinohara Mizuki Miura Akihito Saito Satoshi Kodera Junichi Ishida Norifumi Takeda Hiroyuki Morita Issei Komuro Norihiko Takeda |
| author_sort | Kazutoshi Hirose |
| collection | DOAJ |
| description | Background: Recent data have shown that systemic sclerosis (SSc) is a significant risk factor for coronary artery disease (CAD) and poorer cardiovascular outcomes in the setting of acute coronary syndrome. However, the morphological characteristics of CAD and the long-term cardiovascular outcomes in patients with concurrent SSc and CAD remain unclear. Methods: We retrospectively investigated 3,300 patients with CAD who underwent percutaneous coronary intervention (PCI) without prior myocardial infarction or coronary artery revascularization. Laboratory, echocardiographic and angiographic characteristics, and clinical outcomes were compared between patients with and without SSc according to a 1:3 propensity score-matching analysis adjusted for patient demographics and comorbidities. The primary outcome was a composite of cardiac death, myocardial infarction, and stroke, and the secondary outcome was a composite of the primary outcome and heart failure hospitalization. Results: Among all 3,300 patients, 17 (0.5 %) had SSc. The patients were classified into an SSc group (n = 17) and non-SSc group (n = 51) by propensity score matching. There were no significant differences in laboratory or echocardiographic parameters between the two groups. However, CAD tended to be more complex in the SSc group because of the higher proportion of left main trunk lesions (p = 0.100) and higher SYNergy between PCI with TAXUS™ and Cardiac Surgery (SYNTAX) score (p = 0.030). During a median follow-up of 3.1 years, patients with SSc more frequently experienced primary and secondary outcomes than those without SSc (both log-rank p < 0.02). Conclusions: Among patients with CAD, long-term cardiovascular outcomes after PCI were poorer in those with than without SSc. |
| format | Article |
| id | doaj-art-3a10b0769b074dc89c777cc9467febe8 |
| institution | Kabale University |
| issn | 2352-9067 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-3a10b0769b074dc89c777cc9467febe82025-02-06T05:12:27ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672025-04-0157101625Long-term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosisKazutoshi Hirose0Hiroyuki Kiriyama1Shun Minatsuki2Yugo Nagae3Tatsuki Furusawa4Takashi Hiruma5Atsushi Kobayashi6Masataka Sato7Shinnosuke Sawano8Tatsuya Kamon9Hiroki Shinohara10Mizuki Miura11Akihito Saito12Satoshi Kodera13Junichi Ishida14Norifumi Takeda15Hiroyuki Morita16Issei Komuro17Norihiko Takeda18Department of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo Japan; Corresponding author at: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.Department of Healthcare Information Systems The University of Tokyo Tokyo Japan; Department of Medical Safety Engineering Graduate School of Medical Sciences Kitasato University Kanagawa JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo Japan; Department of Frontier Cardiovascular Science The University of Tokyo Tokyo Japan; International University of Health and Welfare Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanBackground: Recent data have shown that systemic sclerosis (SSc) is a significant risk factor for coronary artery disease (CAD) and poorer cardiovascular outcomes in the setting of acute coronary syndrome. However, the morphological characteristics of CAD and the long-term cardiovascular outcomes in patients with concurrent SSc and CAD remain unclear. Methods: We retrospectively investigated 3,300 patients with CAD who underwent percutaneous coronary intervention (PCI) without prior myocardial infarction or coronary artery revascularization. Laboratory, echocardiographic and angiographic characteristics, and clinical outcomes were compared between patients with and without SSc according to a 1:3 propensity score-matching analysis adjusted for patient demographics and comorbidities. The primary outcome was a composite of cardiac death, myocardial infarction, and stroke, and the secondary outcome was a composite of the primary outcome and heart failure hospitalization. Results: Among all 3,300 patients, 17 (0.5 %) had SSc. The patients were classified into an SSc group (n = 17) and non-SSc group (n = 51) by propensity score matching. There were no significant differences in laboratory or echocardiographic parameters between the two groups. However, CAD tended to be more complex in the SSc group because of the higher proportion of left main trunk lesions (p = 0.100) and higher SYNergy between PCI with TAXUS™ and Cardiac Surgery (SYNTAX) score (p = 0.030). During a median follow-up of 3.1 years, patients with SSc more frequently experienced primary and secondary outcomes than those without SSc (both log-rank p < 0.02). Conclusions: Among patients with CAD, long-term cardiovascular outcomes after PCI were poorer in those with than without SSc.http://www.sciencedirect.com/science/article/pii/S2352906725000284Cardiovascular outcomeSystemic sclerosisCoronary artery diseasePercutaneous coronary intervention |
| spellingShingle | Kazutoshi Hirose Hiroyuki Kiriyama Shun Minatsuki Yugo Nagae Tatsuki Furusawa Takashi Hiruma Atsushi Kobayashi Masataka Sato Shinnosuke Sawano Tatsuya Kamon Hiroki Shinohara Mizuki Miura Akihito Saito Satoshi Kodera Junichi Ishida Norifumi Takeda Hiroyuki Morita Issei Komuro Norihiko Takeda Long-term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosis International Journal of Cardiology: Heart & Vasculature Cardiovascular outcome Systemic sclerosis Coronary artery disease Percutaneous coronary intervention |
| title | Long-term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosis |
| title_full | Long-term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosis |
| title_fullStr | Long-term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosis |
| title_full_unstemmed | Long-term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosis |
| title_short | Long-term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosis |
| title_sort | long term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosis |
| topic | Cardiovascular outcome Systemic sclerosis Coronary artery disease Percutaneous coronary intervention |
| url | http://www.sciencedirect.com/science/article/pii/S2352906725000284 |
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