Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann Reaction: Investigation of Antimicrobial Activities
In the present investigation, 1,2,4-triazole appended to pyrazoline and pyrazole rings (4a–g) using N-arylsydnone as synthon was prepared. The title compounds were subjected to Osiris property explorer for the oral bioavailability to analyze their drug likeness and drug score. Further, the compounds...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/909706 |
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| author | Tasneem Taj Ravindra R. Kamble Atukuri Dorababu Gangadhar Y. Meti |
| author_facet | Tasneem Taj Ravindra R. Kamble Atukuri Dorababu Gangadhar Y. Meti |
| author_sort | Tasneem Taj |
| collection | DOAJ |
| description | In the present investigation, 1,2,4-triazole appended to pyrazoline and pyrazole rings (4a–g) using N-arylsydnone as synthon was prepared. The title compounds were subjected to Osiris property explorer for the oral bioavailability to analyze their drug likeness and drug score. Further, the compounds were subjected to the antimicrobial activity and analyzed the IC 50 and MIC values. |
| format | Article |
| id | doaj-art-3a073ee52ae647718ea8dae7d15b86a4 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-3a073ee52ae647718ea8dae7d15b86a42025-02-03T05:50:41ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/909706909706Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann Reaction: Investigation of Antimicrobial ActivitiesTasneem Taj0Ravindra R. Kamble1Atukuri Dorababu2Gangadhar Y. Meti3Department of Studies in Chemistry, Karnatak University Dharwad, Dharwad 580 003, IndiaDepartment of Studies in Chemistry, Karnatak University Dharwad, Dharwad 580 003, IndiaDepartment of Studies in Chemistry, Karnatak University Dharwad, Dharwad 580 003, IndiaDepartment of Studies in Chemistry, Karnatak University Dharwad, Dharwad 580 003, IndiaIn the present investigation, 1,2,4-triazole appended to pyrazoline and pyrazole rings (4a–g) using N-arylsydnone as synthon was prepared. The title compounds were subjected to Osiris property explorer for the oral bioavailability to analyze their drug likeness and drug score. Further, the compounds were subjected to the antimicrobial activity and analyzed the IC 50 and MIC values.http://dx.doi.org/10.1155/2013/909706 |
| spellingShingle | Tasneem Taj Ravindra R. Kamble Atukuri Dorababu Gangadhar Y. Meti Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann Reaction: Investigation of Antimicrobial Activities Journal of Chemistry |
| title | Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann Reaction: Investigation of Antimicrobial Activities |
| title_full | Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann Reaction: Investigation of Antimicrobial Activities |
| title_fullStr | Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann Reaction: Investigation of Antimicrobial Activities |
| title_full_unstemmed | Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann Reaction: Investigation of Antimicrobial Activities |
| title_short | Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann Reaction: Investigation of Antimicrobial Activities |
| title_sort | synthesis of novel 1 2 4 triazole derivatives as antimicrobial agents via the japp klingemann reaction investigation of antimicrobial activities |
| url | http://dx.doi.org/10.1155/2013/909706 |
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