Antifibrotic Activity of Acylated and Unacylated Ghrelin
Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fi...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/385682 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551728470294528 |
|---|---|
| author | Elia Angelino Simone Reano Michele Ferrara Emanuela Agosti Andrea Graziani Nicoletta Filigheddu |
| author_facet | Elia Angelino Simone Reano Michele Ferrara Emanuela Agosti Andrea Graziani Nicoletta Filigheddu |
| author_sort | Elia Angelino |
| collection | DOAJ |
| description | Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fibroblast activation and pathological deposition of extracellular matrix. Acylated and unacylated ghrelin are the main products of the ghrelin gene. The acylated form, through its receptor GHSR-1a, stimulates appetite and growth hormone (GH) release. Although unacylated ghrelin does not bind or activate GHSR-1a, it shares with the acylated form several biological activities. Ghrelin peptides exhibit anti-inflammatory, antioxidative, and antiapoptotic activities, suggesting that they might represent an efficient approach to prevent or reduce fibrosis. The aim of this review is to summarize the available evidence regarding the effects of acylated and unacylated ghrelin on different pathologies and experimental models in which fibrosis is a predominant characteristic. |
| format | Article |
| id | doaj-art-39e656581fa14d888d62e69e16cfa5f4 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-39e656581fa14d888d62e69e16cfa5f42025-02-03T06:00:40ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/385682385682Antifibrotic Activity of Acylated and Unacylated GhrelinElia Angelino0Simone Reano1Michele Ferrara2Emanuela Agosti3Andrea Graziani4Nicoletta Filigheddu5Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, ItalyDepartment of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, ItalyDepartment of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, ItalyDepartment of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, ItalyDepartment of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, ItalyDepartment of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, ItalyFibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fibroblast activation and pathological deposition of extracellular matrix. Acylated and unacylated ghrelin are the main products of the ghrelin gene. The acylated form, through its receptor GHSR-1a, stimulates appetite and growth hormone (GH) release. Although unacylated ghrelin does not bind or activate GHSR-1a, it shares with the acylated form several biological activities. Ghrelin peptides exhibit anti-inflammatory, antioxidative, and antiapoptotic activities, suggesting that they might represent an efficient approach to prevent or reduce fibrosis. The aim of this review is to summarize the available evidence regarding the effects of acylated and unacylated ghrelin on different pathologies and experimental models in which fibrosis is a predominant characteristic.http://dx.doi.org/10.1155/2015/385682 |
| spellingShingle | Elia Angelino Simone Reano Michele Ferrara Emanuela Agosti Andrea Graziani Nicoletta Filigheddu Antifibrotic Activity of Acylated and Unacylated Ghrelin International Journal of Endocrinology |
| title | Antifibrotic Activity of Acylated and Unacylated Ghrelin |
| title_full | Antifibrotic Activity of Acylated and Unacylated Ghrelin |
| title_fullStr | Antifibrotic Activity of Acylated and Unacylated Ghrelin |
| title_full_unstemmed | Antifibrotic Activity of Acylated and Unacylated Ghrelin |
| title_short | Antifibrotic Activity of Acylated and Unacylated Ghrelin |
| title_sort | antifibrotic activity of acylated and unacylated ghrelin |
| url | http://dx.doi.org/10.1155/2015/385682 |
| work_keys_str_mv | AT eliaangelino antifibroticactivityofacylatedandunacylatedghrelin AT simonereano antifibroticactivityofacylatedandunacylatedghrelin AT micheleferrara antifibroticactivityofacylatedandunacylatedghrelin AT emanuelaagosti antifibroticactivityofacylatedandunacylatedghrelin AT andreagraziani antifibroticactivityofacylatedandunacylatedghrelin AT nicolettafiligheddu antifibroticactivityofacylatedandunacylatedghrelin |