Transcription factor specificity protein (SP) family in renal physiology and diseases
Dysregulated specificity proteins (SPs), members of the C2H2 zinc-finger family, are crucial transcription factors (TFs) with implications for renal physiology and diseases. This comprehensive review focuses on the role of SP family members, particularly SP1 and SP3, in renal physiology and patholog...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2025-01-01
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| Online Access: | https://peerj.com/articles/18820.pdf |
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| author | Wei Zhou Jiaxi Fang Qingqing Jia Hanyan Meng Fei Liu Jianhua Mao |
| author_facet | Wei Zhou Jiaxi Fang Qingqing Jia Hanyan Meng Fei Liu Jianhua Mao |
| author_sort | Wei Zhou |
| collection | DOAJ |
| description | Dysregulated specificity proteins (SPs), members of the C2H2 zinc-finger family, are crucial transcription factors (TFs) with implications for renal physiology and diseases. This comprehensive review focuses on the role of SP family members, particularly SP1 and SP3, in renal physiology and pathology. A detailed analysis of their expression and cellular localization in the healthy human kidney is presented, highlighting their involvement in fatty acid metabolism, electrolyte regulation, and the synthesis of important molecules. The review also delves into the diverse roles of SPs in various renal diseases, including renal ischemia/reperfusion injury, diabetic nephropathy, renal interstitial fibrosis, and lupus nephritis, elucidating their molecular mechanisms and potential as therapeutic targets. The review further discusses pharmacological modulation of SPs and its implications for treatment. Our findings provide a comprehensive understanding of SPs in renal health and disease, offering new avenues for targeted therapeutic interventions and precision medicine in nephrology. |
| format | Article |
| id | doaj-art-39e2c958ff4e4b44ab268bc284bb786e |
| institution | Kabale University |
| issn | 2167-8359 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj-art-39e2c958ff4e4b44ab268bc284bb786e2025-01-22T15:05:19ZengPeerJ Inc.PeerJ2167-83592025-01-0113e1882010.7717/peerj.18820Transcription factor specificity protein (SP) family in renal physiology and diseasesWei Zhou0Jiaxi Fang1Qingqing Jia2Hanyan Meng3Fei Liu4Jianhua Mao5Department of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, ChinaDepartment of Ultrasound, Taizhou Central Hospital, Taizhou, Zhejiang, ChinaShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, ChinaDepartment of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, ChinaDysregulated specificity proteins (SPs), members of the C2H2 zinc-finger family, are crucial transcription factors (TFs) with implications for renal physiology and diseases. This comprehensive review focuses on the role of SP family members, particularly SP1 and SP3, in renal physiology and pathology. A detailed analysis of their expression and cellular localization in the healthy human kidney is presented, highlighting their involvement in fatty acid metabolism, electrolyte regulation, and the synthesis of important molecules. The review also delves into the diverse roles of SPs in various renal diseases, including renal ischemia/reperfusion injury, diabetic nephropathy, renal interstitial fibrosis, and lupus nephritis, elucidating their molecular mechanisms and potential as therapeutic targets. The review further discusses pharmacological modulation of SPs and its implications for treatment. Our findings provide a comprehensive understanding of SPs in renal health and disease, offering new avenues for targeted therapeutic interventions and precision medicine in nephrology.https://peerj.com/articles/18820.pdfTranscription factor specificity proteinRenal physiologyDiabetic nephropathyRenal ischemia/reperfusion injuryRenal fibrosisRenal tumor |
| spellingShingle | Wei Zhou Jiaxi Fang Qingqing Jia Hanyan Meng Fei Liu Jianhua Mao Transcription factor specificity protein (SP) family in renal physiology and diseases PeerJ Transcription factor specificity protein Renal physiology Diabetic nephropathy Renal ischemia/reperfusion injury Renal fibrosis Renal tumor |
| title | Transcription factor specificity protein (SP) family in renal physiology and diseases |
| title_full | Transcription factor specificity protein (SP) family in renal physiology and diseases |
| title_fullStr | Transcription factor specificity protein (SP) family in renal physiology and diseases |
| title_full_unstemmed | Transcription factor specificity protein (SP) family in renal physiology and diseases |
| title_short | Transcription factor specificity protein (SP) family in renal physiology and diseases |
| title_sort | transcription factor specificity protein sp family in renal physiology and diseases |
| topic | Transcription factor specificity protein Renal physiology Diabetic nephropathy Renal ischemia/reperfusion injury Renal fibrosis Renal tumor |
| url | https://peerj.com/articles/18820.pdf |
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