T cell receptor signaling and cell immunotherapy
As the major sensor of adaptive immune system, T cell receptor (TCR) can recognize diverse antigens and initiate specific immune responses against invading pathogens and cancer cells. Understanding the mechanisms of TCR signaling has led to the development of engineered T cell therapies, which have...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Science Press
2024-03-01
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| Series: | National Science Open |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.1360/nso/20230087 |
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| _version_ | 1849708517777211392 |
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| author | Zhang Linsong Xu Xinyi Shi Xiaoshan Xu Chenqi |
| author_facet | Zhang Linsong Xu Xinyi Shi Xiaoshan Xu Chenqi |
| author_sort | Zhang Linsong |
| collection | DOAJ |
| description | As the major sensor of adaptive immune system, T cell receptor (TCR) can recognize diverse antigens and initiate specific immune responses against invading pathogens and cancer cells. Understanding the mechanisms of TCR signaling has led to the development of engineered T cell therapies, which have extensive applications in the treatment of diseases such as cancer, infection and autoimmunity. Here, we review the current understanding of antigen-induced TCR signaling and discuss its applications in T cell therapies. |
| format | Article |
| id | doaj-art-39e15d6dbced48a7b4fa8a7bd2e4eaae |
| institution | DOAJ |
| issn | 2097-1168 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Science Press |
| record_format | Article |
| series | National Science Open |
| spelling | doaj-art-39e15d6dbced48a7b4fa8a7bd2e4eaae2025-08-20T03:15:38ZengScience PressNational Science Open2097-11682024-03-01310.1360/nso/20230087eb33e642T cell receptor signaling and cell immunotherapyZhang Linsong0Xu Xinyi1Shi Xiaoshan2Xu Chenqi3["Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"]["State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China"]["Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"]["State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China"]As the major sensor of adaptive immune system, T cell receptor (TCR) can recognize diverse antigens and initiate specific immune responses against invading pathogens and cancer cells. Understanding the mechanisms of TCR signaling has led to the development of engineered T cell therapies, which have extensive applications in the treatment of diseases such as cancer, infection and autoimmunity. Here, we review the current understanding of antigen-induced TCR signaling and discuss its applications in T cell therapies.https://www.sciengine.com/doi/10.1360/nso/20230087T cell receptor-CD3 complexsignalingT cell therapy |
| spellingShingle | Zhang Linsong Xu Xinyi Shi Xiaoshan Xu Chenqi T cell receptor signaling and cell immunotherapy National Science Open T cell receptor-CD3 complex signaling T cell therapy |
| title | T cell receptor signaling and cell immunotherapy |
| title_full | T cell receptor signaling and cell immunotherapy |
| title_fullStr | T cell receptor signaling and cell immunotherapy |
| title_full_unstemmed | T cell receptor signaling and cell immunotherapy |
| title_short | T cell receptor signaling and cell immunotherapy |
| title_sort | t cell receptor signaling and cell immunotherapy |
| topic | T cell receptor-CD3 complex signaling T cell therapy |
| url | https://www.sciengine.com/doi/10.1360/nso/20230087 |
| work_keys_str_mv | AT zhanglinsong tcellreceptorsignalingandcellimmunotherapy AT xuxinyi tcellreceptorsignalingandcellimmunotherapy AT shixiaoshan tcellreceptorsignalingandcellimmunotherapy AT xuchenqi tcellreceptorsignalingandcellimmunotherapy |