Enhancing sleep quality in synucleinopathies through physical exercise
During sleep, several crucial processes for brain homeostasis occur, including the rearrangement of synaptic connections, which is essential for memory formation and updating. Sleep also facilitates the removal of neurotoxic waste products, the accumulation of which plays a key role in neurodegenera...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2025.1515922/full |
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| author | Jacopo Canonichesi Laura Bellingacci Francesco Rivelli Alessandro Tozzi |
| author_facet | Jacopo Canonichesi Laura Bellingacci Francesco Rivelli Alessandro Tozzi |
| author_sort | Jacopo Canonichesi |
| collection | DOAJ |
| description | During sleep, several crucial processes for brain homeostasis occur, including the rearrangement of synaptic connections, which is essential for memory formation and updating. Sleep also facilitates the removal of neurotoxic waste products, the accumulation of which plays a key role in neurodegeneration. Various neural components and environmental factors regulate and influence the physiological transition between wakefulness and sleep. Disruptions in this complex system form the basis of sleep disorders, as commonly observed in synucleinopathies. Synucleinopathies are neurodegenerative disorders characterized by abnormal build-up of α-synuclein protein aggregates in the brain. This accumulation in different brain regions leads to a spectrum of clinical manifestations, including hypokinesia, cognitive impairment, psychiatric symptoms, and neurovegetative disturbances. Sleep disorders are highly prevalent in individuals with synucleinopathies, and they not only affect the overall well-being of patients but also directly contribute to disease severity and progression. Therefore, it is crucial to develop effective therapeutic strategies to improve sleep quality in these patients. Adequate sleep is vital for brain health, and the role of synucleinopathies in disrupting sleep patterns must be taken into account. In this context, it is essential to explore the role of physical exercise as a potential non-pharmacological intervention to manage sleep disorders in individuals with synucleinopathies. The current evidence on the efficacy of exercise programs to enhance sleep quality in this patient population is discussed. |
| format | Article |
| id | doaj-art-39dd8487d61d4a65bbf7b88710d11d71 |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-39dd8487d61d4a65bbf7b88710d11d712025-01-31T06:40:19ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-01-011910.3389/fncel.2025.15159221515922Enhancing sleep quality in synucleinopathies through physical exerciseJacopo CanonichesiLaura BellingacciFrancesco RivelliAlessandro TozziDuring sleep, several crucial processes for brain homeostasis occur, including the rearrangement of synaptic connections, which is essential for memory formation and updating. Sleep also facilitates the removal of neurotoxic waste products, the accumulation of which plays a key role in neurodegeneration. Various neural components and environmental factors regulate and influence the physiological transition between wakefulness and sleep. Disruptions in this complex system form the basis of sleep disorders, as commonly observed in synucleinopathies. Synucleinopathies are neurodegenerative disorders characterized by abnormal build-up of α-synuclein protein aggregates in the brain. This accumulation in different brain regions leads to a spectrum of clinical manifestations, including hypokinesia, cognitive impairment, psychiatric symptoms, and neurovegetative disturbances. Sleep disorders are highly prevalent in individuals with synucleinopathies, and they not only affect the overall well-being of patients but also directly contribute to disease severity and progression. Therefore, it is crucial to develop effective therapeutic strategies to improve sleep quality in these patients. Adequate sleep is vital for brain health, and the role of synucleinopathies in disrupting sleep patterns must be taken into account. In this context, it is essential to explore the role of physical exercise as a potential non-pharmacological intervention to manage sleep disorders in individuals with synucleinopathies. The current evidence on the efficacy of exercise programs to enhance sleep quality in this patient population is discussed.https://www.frontiersin.org/articles/10.3389/fncel.2025.1515922/fullneurodegenerationnon-pharmacological interventionphysical exercisesleep disturbancessleep hygienesynucleinopathies |
| spellingShingle | Jacopo Canonichesi Laura Bellingacci Francesco Rivelli Alessandro Tozzi Enhancing sleep quality in synucleinopathies through physical exercise Frontiers in Cellular Neuroscience neurodegeneration non-pharmacological intervention physical exercise sleep disturbances sleep hygiene synucleinopathies |
| title | Enhancing sleep quality in synucleinopathies through physical exercise |
| title_full | Enhancing sleep quality in synucleinopathies through physical exercise |
| title_fullStr | Enhancing sleep quality in synucleinopathies through physical exercise |
| title_full_unstemmed | Enhancing sleep quality in synucleinopathies through physical exercise |
| title_short | Enhancing sleep quality in synucleinopathies through physical exercise |
| title_sort | enhancing sleep quality in synucleinopathies through physical exercise |
| topic | neurodegeneration non-pharmacological intervention physical exercise sleep disturbances sleep hygiene synucleinopathies |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2025.1515922/full |
| work_keys_str_mv | AT jacopocanonichesi enhancingsleepqualityinsynucleinopathiesthroughphysicalexercise AT laurabellingacci enhancingsleepqualityinsynucleinopathiesthroughphysicalexercise AT francescorivelli enhancingsleepqualityinsynucleinopathiesthroughphysicalexercise AT alessandrotozzi enhancingsleepqualityinsynucleinopathiesthroughphysicalexercise |