Host Genetic Factors in Q Fever Susceptibility
Several indirect findings suggest that host-related factors influence susceptibility to <i>Coxiella burnetii</i> infection. We decided to explore the influence of genetic factors related to both innate and adaptive immunity in acute Q fever susceptibility. TLR2 (Arg753Gln) and TLR4 (Asp2...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/14/4/394 |
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| author | José-María Robaina Bordón José-Luis Pérez-Arellano Olga Montes-Ares Alberto Torio-Ruiz Michele Hernández-Cabrera Elena Pisos-Álamo Cristina Carranza-Rodríguez |
| author_facet | José-María Robaina Bordón José-Luis Pérez-Arellano Olga Montes-Ares Alberto Torio-Ruiz Michele Hernández-Cabrera Elena Pisos-Álamo Cristina Carranza-Rodríguez |
| author_sort | José-María Robaina Bordón |
| collection | DOAJ |
| description | Several indirect findings suggest that host-related factors influence susceptibility to <i>Coxiella burnetii</i> infection. We decided to explore the influence of genetic factors related to both innate and adaptive immunity in acute Q fever susceptibility. TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) polymorphisms, along with HLA-DRB1 alleles, were analyzed for 38 patients with acute Q fever, 38 matched controls, and 121 blood donors. No significant associations were found for TLR polymorphisms. However, HLA-DRB1*04 was more frequent in patients. HLA-DRB1 variants may play a role in Q fever susceptibility, supporting the need for further investigation into their potential implications for vaccination and risk assessment. |
| format | Article |
| id | doaj-art-39ca0f251d8d4de4a917077dd2b05ab9 |
| institution | OA Journals |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-39ca0f251d8d4de4a917077dd2b05ab92025-08-20T02:18:00ZengMDPI AGPathogens2076-08172025-04-0114439410.3390/pathogens14040394Host Genetic Factors in Q Fever SusceptibilityJosé-María Robaina Bordón0José-Luis Pérez-Arellano1Olga Montes-Ares2Alberto Torio-Ruiz3Michele Hernández-Cabrera4Elena Pisos-Álamo5Cristina Carranza-Rodríguez6Department of Clinical and Surgical Sciences, University of Las Palmas de Gran Canaria [ULPGC], 35001 Las Palmas de Gran Canaria, SpainUniversity Institute of Biomedical and Health Research [IUIBS], University of Las Palmas de Gran Canaria [ULPGC], 35016 Las Palmas de Gran Canaria, SpainHospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, SpainDepartment of Immunology, Hospital General Universitario de Albacete, 02006 Albacete, SpainDepartment of Clinical and Surgical Sciences, University of Las Palmas de Gran Canaria [ULPGC], 35001 Las Palmas de Gran Canaria, SpainDepartment of Clinical and Surgical Sciences, University of Las Palmas de Gran Canaria [ULPGC], 35001 Las Palmas de Gran Canaria, SpainDepartment of Clinical and Surgical Sciences, University of Las Palmas de Gran Canaria [ULPGC], 35001 Las Palmas de Gran Canaria, SpainSeveral indirect findings suggest that host-related factors influence susceptibility to <i>Coxiella burnetii</i> infection. We decided to explore the influence of genetic factors related to both innate and adaptive immunity in acute Q fever susceptibility. TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) polymorphisms, along with HLA-DRB1 alleles, were analyzed for 38 patients with acute Q fever, 38 matched controls, and 121 blood donors. No significant associations were found for TLR polymorphisms. However, HLA-DRB1*04 was more frequent in patients. HLA-DRB1 variants may play a role in Q fever susceptibility, supporting the need for further investigation into their potential implications for vaccination and risk assessment.https://www.mdpi.com/2076-0817/14/4/394<i>Coxiella burnetii</i>Q feverhost genetic factors |
| spellingShingle | José-María Robaina Bordón José-Luis Pérez-Arellano Olga Montes-Ares Alberto Torio-Ruiz Michele Hernández-Cabrera Elena Pisos-Álamo Cristina Carranza-Rodríguez Host Genetic Factors in Q Fever Susceptibility Pathogens <i>Coxiella burnetii</i> Q fever host genetic factors |
| title | Host Genetic Factors in Q Fever Susceptibility |
| title_full | Host Genetic Factors in Q Fever Susceptibility |
| title_fullStr | Host Genetic Factors in Q Fever Susceptibility |
| title_full_unstemmed | Host Genetic Factors in Q Fever Susceptibility |
| title_short | Host Genetic Factors in Q Fever Susceptibility |
| title_sort | host genetic factors in q fever susceptibility |
| topic | <i>Coxiella burnetii</i> Q fever host genetic factors |
| url | https://www.mdpi.com/2076-0817/14/4/394 |
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