Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status
Previous studies have investigated extrahepatic multiple primary malignancy (EHPM) associated with hepatocellular carcinoma (HCC). However, its correlation with viral infection, such as hepatitis B virus (HBV) or hepatitis C virus (HCV), has not been examined. The aim of this study is to investigate...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/495950 |
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| author | Keita Kai Atsushi Miyoshi Kenji Kitahara Masanori Masuda Yukari Takase Kohji Miyazaki Hirokazu Noshiro Osamu Tokunaga |
| author_facet | Keita Kai Atsushi Miyoshi Kenji Kitahara Masanori Masuda Yukari Takase Kohji Miyazaki Hirokazu Noshiro Osamu Tokunaga |
| author_sort | Keita Kai |
| collection | DOAJ |
| description | Previous studies have investigated extrahepatic multiple primary malignancy (EHPM) associated with hepatocellular carcinoma (HCC). However, its correlation with viral infection, such as hepatitis B virus (HBV) or hepatitis C virus (HCV), has not been examined. The aim of this study is to investigate the association between EHPM and hepatitis infection in HCC patients. A total of 412 patients who underwent surgical resection for primary HCC were enrolled. Viral infection was evaluated by serum HBV surface antigen (HBs Ag) and HCV antibody (HCV Ab). Sixty-eight (16.5%) patients had one or more EHPM. The most frequent EHPM was gastric cancer () in this cohort. No statistical significance was observed in the distribution of viral infection and incidence of entire EHPM. However, HCV Ab, HBs Ag, and negative status for both were correlated with the frequency of gastric (), urinary tract (), and breast cancer (), respectively. Infection of Helicobacter pylori was investigated by immunohistochemistry in gastric EHPM and resulted that 20 out of 21 analyzed cases were negative for Helicobacter pylori. Although it should be verified by well-designed large cohort studies, the current results suggested correlation between HCV infection and gastric cancer, HBV infection and urinary tract cancer and viral hepatitis-free status and breast cancer in HCC patients. |
| format | Article |
| id | doaj-art-39bfd979db904b6c992b59bf8d1ef45d |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-39bfd979db904b6c992b59bf8d1ef45d2025-02-03T05:46:39ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/495950495950Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection StatusKeita Kai0Atsushi Miyoshi1Kenji Kitahara2Masanori Masuda3Yukari Takase4Kohji Miyazaki5Hirokazu Noshiro6Osamu Tokunaga7Departments of Pathology and Microbiology, Faculty of Medicine, Saga University, Nabesima 5-1-1, Saga City 849-8501, Saga, JapanDepartment of Surgery, Faculty of Medicine, Saga University, Saga City 849-8501, Saga, JapanDepartment of Surgery, Faculty of Medicine, Saga University, Saga City 849-8501, Saga, JapanDepartments of Pathology and Microbiology, Faculty of Medicine, Saga University, Nabesima 5-1-1, Saga City 849-8501, Saga, JapanDepartments of Pathology and Microbiology, Faculty of Medicine, Saga University, Nabesima 5-1-1, Saga City 849-8501, Saga, JapanDepartment of Surgery, Faculty of Medicine, Saga University, Saga City 849-8501, Saga, JapanDepartment of Surgery, Faculty of Medicine, Saga University, Saga City 849-8501, Saga, JapanDepartments of Pathology and Microbiology, Faculty of Medicine, Saga University, Nabesima 5-1-1, Saga City 849-8501, Saga, JapanPrevious studies have investigated extrahepatic multiple primary malignancy (EHPM) associated with hepatocellular carcinoma (HCC). However, its correlation with viral infection, such as hepatitis B virus (HBV) or hepatitis C virus (HCV), has not been examined. The aim of this study is to investigate the association between EHPM and hepatitis infection in HCC patients. A total of 412 patients who underwent surgical resection for primary HCC were enrolled. Viral infection was evaluated by serum HBV surface antigen (HBs Ag) and HCV antibody (HCV Ab). Sixty-eight (16.5%) patients had one or more EHPM. The most frequent EHPM was gastric cancer () in this cohort. No statistical significance was observed in the distribution of viral infection and incidence of entire EHPM. However, HCV Ab, HBs Ag, and negative status for both were correlated with the frequency of gastric (), urinary tract (), and breast cancer (), respectively. Infection of Helicobacter pylori was investigated by immunohistochemistry in gastric EHPM and resulted that 20 out of 21 analyzed cases were negative for Helicobacter pylori. Although it should be verified by well-designed large cohort studies, the current results suggested correlation between HCV infection and gastric cancer, HBV infection and urinary tract cancer and viral hepatitis-free status and breast cancer in HCC patients.http://dx.doi.org/10.1155/2012/495950 |
| spellingShingle | Keita Kai Atsushi Miyoshi Kenji Kitahara Masanori Masuda Yukari Takase Kohji Miyazaki Hirokazu Noshiro Osamu Tokunaga Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status International Journal of Hepatology |
| title | Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status |
| title_full | Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status |
| title_fullStr | Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status |
| title_full_unstemmed | Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status |
| title_short | Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status |
| title_sort | analysis of extrahepatic multiple primary malignancies in patients with hepatocellular carcinoma according to viral infection status |
| url | http://dx.doi.org/10.1155/2012/495950 |
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