Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia

Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia

Summary: Focal cortical dysplasia (FCD) is a neurodevelopmental condition characterized by malformations of the cerebral cortex that often cause drug-resistant epilepsy. In this study, we performed multi-omics single-nuclei profiling to map the chromatin accessibility and transcriptome landscapes of...

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Main Authors: Isabella C. Galvão, Manuela Lemoine, Lauana A. Messias, Patrícia A.O.R.A. Araújo, Jaqueline C. Geraldis, Clarissa L. Yasuda, Marina K.M. Alvim, Enrico Ghizoni, Helder Tedeschi, Fernando Cendes, Fabio Rogerio, Iscia Lopes-Cendes, Diogo F.T. Veiga
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Biological sciences
Neuroscience
Developmental neuroscience
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224025628
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