Toxic Epidermal Necrolysis-Like Lesions and Systemic Lupus Erythematosus Possibly Triggered by Sulfasalazine
This case report describes a patient with arthritis of the large joints, bilateral sacroiliitis, and positive anti-SSA and anti-dsDNA antibody, who received sulfasalazine and shortly thereafter became critically ill. He developed toxic epidermal necrolysis, hemolytic anemia, lymphopenia, markedly el...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2016/4501937 |
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| author | Simon Krabbe Cigdem Gül Bjarne Andersen Niels Tvede |
| author_facet | Simon Krabbe Cigdem Gül Bjarne Andersen Niels Tvede |
| author_sort | Simon Krabbe |
| collection | DOAJ |
| description | This case report describes a patient with arthritis of the large joints, bilateral sacroiliitis, and positive anti-SSA and anti-dsDNA antibody, who received sulfasalazine and shortly thereafter became critically ill. He developed toxic epidermal necrolysis, hemolytic anemia, lymphopenia, markedly elevated ferritin, and muscle wasting. A diagnosis of systemic lupus erythematosus was made, and mycophenolate mofetil and systemic glucocorticoids brought this severe disease under control. Toxic epidermal necrolysis-like lesions and hemophagocytic syndrome have been reported as manifestations of systemic lupus erythematosus. This patient possibly had spondyloarthritis or an undifferentiated connective tissue disease at presentation, and we suggest, based on the timing of events, that sulfasalazine may have acted as a trigger of the severe disease manifestations. |
| format | Article |
| id | doaj-art-39b0bdedb8024ff9a264a888c6eeceda |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-39b0bdedb8024ff9a264a888c6eeceda2025-02-03T01:31:23ZengWileyCase Reports in Rheumatology2090-68892090-68972016-01-01201610.1155/2016/45019374501937Toxic Epidermal Necrolysis-Like Lesions and Systemic Lupus Erythematosus Possibly Triggered by SulfasalazineSimon Krabbe0Cigdem Gül1Bjarne Andersen2Niels Tvede3Center for Rheumatology and Spine Diseases, Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Dermatology, Gentofte Hospital, 2900 Hellerup, DenmarkDepartment of Rheumatology, Nordsjællands Hospital, 3400 Hillerød, DenmarkCenter for Rheumatology and Spine Diseases, Rigshospitalet, 2100 Copenhagen, DenmarkThis case report describes a patient with arthritis of the large joints, bilateral sacroiliitis, and positive anti-SSA and anti-dsDNA antibody, who received sulfasalazine and shortly thereafter became critically ill. He developed toxic epidermal necrolysis, hemolytic anemia, lymphopenia, markedly elevated ferritin, and muscle wasting. A diagnosis of systemic lupus erythematosus was made, and mycophenolate mofetil and systemic glucocorticoids brought this severe disease under control. Toxic epidermal necrolysis-like lesions and hemophagocytic syndrome have been reported as manifestations of systemic lupus erythematosus. This patient possibly had spondyloarthritis or an undifferentiated connective tissue disease at presentation, and we suggest, based on the timing of events, that sulfasalazine may have acted as a trigger of the severe disease manifestations.http://dx.doi.org/10.1155/2016/4501937 |
| spellingShingle | Simon Krabbe Cigdem Gül Bjarne Andersen Niels Tvede Toxic Epidermal Necrolysis-Like Lesions and Systemic Lupus Erythematosus Possibly Triggered by Sulfasalazine Case Reports in Rheumatology |
| title | Toxic Epidermal Necrolysis-Like Lesions and Systemic Lupus Erythematosus Possibly Triggered by Sulfasalazine |
| title_full | Toxic Epidermal Necrolysis-Like Lesions and Systemic Lupus Erythematosus Possibly Triggered by Sulfasalazine |
| title_fullStr | Toxic Epidermal Necrolysis-Like Lesions and Systemic Lupus Erythematosus Possibly Triggered by Sulfasalazine |
| title_full_unstemmed | Toxic Epidermal Necrolysis-Like Lesions and Systemic Lupus Erythematosus Possibly Triggered by Sulfasalazine |
| title_short | Toxic Epidermal Necrolysis-Like Lesions and Systemic Lupus Erythematosus Possibly Triggered by Sulfasalazine |
| title_sort | toxic epidermal necrolysis like lesions and systemic lupus erythematosus possibly triggered by sulfasalazine |
| url | http://dx.doi.org/10.1155/2016/4501937 |
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