Development of a method for simultaneous analysis of glycosaminoglycan disaccharides and evaluating the quality of chondroitin sulfate and hyaluronic acid in food raw materials

Development of a method for simultaneous analysis of glycosaminoglycan disaccharides and evaluating the quality of chondroitin sulfate and hyaluronic acid in food raw materials

We developed a comprehensive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous analysis of 19 glycosaminoglycan disaccharide components. Although structural similarity among components can hinder MS identification, we optimized the LC conditions to successfully se...

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Bibliographic Details
Main Authors: Kengo Hirai, Takamasa Ishii, Ayaka Aijima, Nae Yokota, Yasuhisa Miyamoto, Kyohei Higashi, Yusuke Iwasaki, Rie Ito, Nobuaki Higashi, Hiroshi Akiyama
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Food Chemistry: X
Subjects:
Glycosaminoglycan
Chondroitin sulfate
Hyaluronic acid
Unsaturated disaccharide
Enzymatic digestion
LC-MS/MS
Online Access:http://www.sciencedirect.com/science/article/pii/S2590157525000860
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