Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)

Globally, there has been increasing attention paid to vitamin D deficiency and its treatment. Vitamin D stosstherapy with high-dose ergocalciferol in a single day is reemerging as a potential treatment option. We present an as yet unreported complication of acute renal injury due to propylene glycol...

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Main Authors: David H. Jelley, Deborah Zayneb Mohamad Ali, Michelle Condren
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Case Reports in Endocrinology
Online Access:http://dx.doi.org/10.1155/2019/1482727
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author David H. Jelley
Deborah Zayneb Mohamad Ali
Michelle Condren
author_facet David H. Jelley
Deborah Zayneb Mohamad Ali
Michelle Condren
author_sort David H. Jelley
collection DOAJ
description Globally, there has been increasing attention paid to vitamin D deficiency and its treatment. Vitamin D stosstherapy with high-dose ergocalciferol in a single day is reemerging as a potential treatment option. We present an as yet unreported complication of acute renal injury due to propylene glycol toxicity in a 7-month infant treated with vitamin D stosstherapy. The product label for the vitamin D used for this patient states it is dissolved in propylene glycol (PG), but the amount is not listed on this or other US ergocalciferol liquid products that contain PG. Caution should be used when considering vitamin D stosstherapy with liquid ergocalciferol products available in the United States.
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series Case Reports in Endocrinology
spelling doaj-art-398cb7782c414e0aa500b63d41cb4ab32025-02-03T05:44:14ZengWileyCase Reports in Endocrinology2090-65012090-651X2019-01-01201910.1155/2019/14827271482727Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)David H. Jelley0Deborah Zayneb Mohamad Ali1Michelle Condren2Pediatric Department, University of Oklahoma School of Community Medicine, Tulsa, 4444 E 41st St., Tulsa, OK 74135, 918-619-4803, USAPediatric Department, University of Oklahoma School of Community Medicine, Tulsa, 4502 E 41st St, Tulsa, OK 74135, 918-660-3400, USAUniversity of Oklahoma College of Pharmacy, Pediatric Department, University of Oklahoma School of Community Medicine, Tulsa, 4502 E. 41st St, Tulsa, OK 74135, 918-660-3578, USAGlobally, there has been increasing attention paid to vitamin D deficiency and its treatment. Vitamin D stosstherapy with high-dose ergocalciferol in a single day is reemerging as a potential treatment option. We present an as yet unreported complication of acute renal injury due to propylene glycol toxicity in a 7-month infant treated with vitamin D stosstherapy. The product label for the vitamin D used for this patient states it is dissolved in propylene glycol (PG), but the amount is not listed on this or other US ergocalciferol liquid products that contain PG. Caution should be used when considering vitamin D stosstherapy with liquid ergocalciferol products available in the United States.http://dx.doi.org/10.1155/2019/1482727
spellingShingle David H. Jelley
Deborah Zayneb Mohamad Ali
Michelle Condren
Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)
Case Reports in Endocrinology
title Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)
title_full Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)
title_fullStr Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)
title_full_unstemmed Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)
title_short Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)
title_sort acute renal failure secondary to inadvertent propylene glycol overdose with single day high dose vitamin d stosstherapy
url http://dx.doi.org/10.1155/2019/1482727
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AT michellecondren acuterenalfailuresecondarytoinadvertentpropyleneglycoloverdosewithsingledayhighdosevitamindstosstherapy