Acute Stent Thrombosis Associated with Eptifibatide-Induced Profound Thrombocytopenia
Background. Eptifibatide is an inhibitor of the platelet glycoprotein (GP) IIb/IIIa receptor that is commonly used in patients undergoing percutaneous coronary intervention (PCI). Case. We describe a case of a 62-year-old female patient admitted with acute ST-elevation myocardial infarction (STEMI)...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2020/8386709 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547139398402048 |
|---|---|
| author | Amer Aljundi Alaa Rahhal Wafer Dabdoob |
| author_facet | Amer Aljundi Alaa Rahhal Wafer Dabdoob |
| author_sort | Amer Aljundi |
| collection | DOAJ |
| description | Background. Eptifibatide is an inhibitor of the platelet glycoprotein (GP) IIb/IIIa receptor that is commonly used in patients undergoing percutaneous coronary intervention (PCI). Case. We describe a case of a 62-year-old female patient admitted with acute ST-elevation myocardial infarction (STEMI) treated by primary coronary intervention (primary PCI) with a drug-eluting stent placement. She developed profound thrombocytopenia within 8 hours of first administration of eptifibatide and subsequent acute stent thrombosis next day. Other causes of thrombocytopenia were excluded and intravascular ultrasound (IVUS) showed good stent expansion and opposition to the coronary wall. Platelet count gradually returned to normal after discontinuation of eptifibatide. Conclusion. Although Eptifibatide has been associated with the development of thrombocytopenia, to the best of our knowledge, this is the first case report in the medical literature that associates acute stent thrombosis and eptifibatide-induced thrombocytopenia. |
| format | Article |
| id | doaj-art-396a5c5fb44445c393a98c938752008a |
| institution | Kabale University |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-396a5c5fb44445c393a98c938752008a2025-02-03T06:45:49ZengWileyCase Reports in Cardiology2090-64042090-64122020-01-01202010.1155/2020/83867098386709Acute Stent Thrombosis Associated with Eptifibatide-Induced Profound ThrombocytopeniaAmer Aljundi0Alaa Rahhal1Wafer Dabdoob2Pharmacy Department, Heart Hospital, Hamad Medical Corporation, Doha, QatarPharmacy Department, Heart Hospital, Hamad Medical Corporation, Doha, QatarCardiology and Cardiovascular Surgery Department, Heart Hospital, Hamad Medical Corporation, Doha, QatarBackground. Eptifibatide is an inhibitor of the platelet glycoprotein (GP) IIb/IIIa receptor that is commonly used in patients undergoing percutaneous coronary intervention (PCI). Case. We describe a case of a 62-year-old female patient admitted with acute ST-elevation myocardial infarction (STEMI) treated by primary coronary intervention (primary PCI) with a drug-eluting stent placement. She developed profound thrombocytopenia within 8 hours of first administration of eptifibatide and subsequent acute stent thrombosis next day. Other causes of thrombocytopenia were excluded and intravascular ultrasound (IVUS) showed good stent expansion and opposition to the coronary wall. Platelet count gradually returned to normal after discontinuation of eptifibatide. Conclusion. Although Eptifibatide has been associated with the development of thrombocytopenia, to the best of our knowledge, this is the first case report in the medical literature that associates acute stent thrombosis and eptifibatide-induced thrombocytopenia.http://dx.doi.org/10.1155/2020/8386709 |
| spellingShingle | Amer Aljundi Alaa Rahhal Wafer Dabdoob Acute Stent Thrombosis Associated with Eptifibatide-Induced Profound Thrombocytopenia Case Reports in Cardiology |
| title | Acute Stent Thrombosis Associated with Eptifibatide-Induced Profound Thrombocytopenia |
| title_full | Acute Stent Thrombosis Associated with Eptifibatide-Induced Profound Thrombocytopenia |
| title_fullStr | Acute Stent Thrombosis Associated with Eptifibatide-Induced Profound Thrombocytopenia |
| title_full_unstemmed | Acute Stent Thrombosis Associated with Eptifibatide-Induced Profound Thrombocytopenia |
| title_short | Acute Stent Thrombosis Associated with Eptifibatide-Induced Profound Thrombocytopenia |
| title_sort | acute stent thrombosis associated with eptifibatide induced profound thrombocytopenia |
| url | http://dx.doi.org/10.1155/2020/8386709 |
| work_keys_str_mv | AT ameraljundi acutestentthrombosisassociatedwitheptifibatideinducedprofoundthrombocytopenia AT alaarahhal acutestentthrombosisassociatedwitheptifibatideinducedprofoundthrombocytopenia AT waferdabdoob acutestentthrombosisassociatedwitheptifibatideinducedprofoundthrombocytopenia |