Age-Related Macular Degeneration: Insights into Inflammatory Genes
Age-related macular degeneration (AMD) is a progressive neurodegenerative disease that affects approximately 8.7% of elderly people worldwide (>55 years old). AMD is characterized by a multifactorial aetiology that involves several genetic and environmental risk factors (genes, ageing, smoking, f...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/582842 |
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| _version_ | 1832547977998106624 |
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| author | Raffaella Cascella Michele Ragazzo Claudia Strafella Filippo Missiroli Paola Borgiani Francesco Angelucci Luigi Tonino Marsella Andrea Cusumano Giuseppe Novelli Federico Ricci Emiliano Giardina |
| author_facet | Raffaella Cascella Michele Ragazzo Claudia Strafella Filippo Missiroli Paola Borgiani Francesco Angelucci Luigi Tonino Marsella Andrea Cusumano Giuseppe Novelli Federico Ricci Emiliano Giardina |
| author_sort | Raffaella Cascella |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) is a progressive neurodegenerative disease that affects approximately 8.7% of elderly people worldwide (>55 years old). AMD is characterized by a multifactorial aetiology that involves several genetic and environmental risk factors (genes, ageing, smoking, family history, dietary habits, oxidative stress, and hypertension). In particular, ageing and cigarette smoking (including oxidative compounds and reactive oxygen species) have been shown to significantly increase susceptibility to the disease. Furthermore, different genes (CFH, CFI, C2, C3, IL-6, IL-8, and ARMS2) that play a crucial role in the inflammatory pathway have been associated with AMD risk. Several genetic and molecular studies have indicated the participation of inflammatory molecules (cytokines and chemokines), immune cells (macrophages), and complement proteins in the development and progression of the disease. Taking into consideration the genetic and molecular background, this review highlights the genetic role of inflammatory genes involved in AMD pathogenesis and progression. |
| format | Article |
| id | doaj-art-3953ce04fc89498d9ec1dedede339d0d |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-3953ce04fc89498d9ec1dedede339d0d2025-02-03T06:42:27ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/582842582842Age-Related Macular Degeneration: Insights into Inflammatory GenesRaffaella Cascella0Michele Ragazzo1Claudia Strafella2Filippo Missiroli3Paola Borgiani4Francesco Angelucci5Luigi Tonino Marsella6Andrea Cusumano7Giuseppe Novelli8Federico Ricci9Emiliano Giardina10Department of Biomedicine and Prevention, School of Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, School of Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, School of Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyUOSD Retinal Pathology PTV Foundation “Policlinico Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, School of Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyMolecular Genetics Laboratory UILDM, Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, ItalyDepartment of Biomedicine and Prevention, School of Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyUOSD Retinal Pathology PTV Foundation “Policlinico Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, School of Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyUOSD Retinal Pathology PTV Foundation “Policlinico Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, School of Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyAge-related macular degeneration (AMD) is a progressive neurodegenerative disease that affects approximately 8.7% of elderly people worldwide (>55 years old). AMD is characterized by a multifactorial aetiology that involves several genetic and environmental risk factors (genes, ageing, smoking, family history, dietary habits, oxidative stress, and hypertension). In particular, ageing and cigarette smoking (including oxidative compounds and reactive oxygen species) have been shown to significantly increase susceptibility to the disease. Furthermore, different genes (CFH, CFI, C2, C3, IL-6, IL-8, and ARMS2) that play a crucial role in the inflammatory pathway have been associated with AMD risk. Several genetic and molecular studies have indicated the participation of inflammatory molecules (cytokines and chemokines), immune cells (macrophages), and complement proteins in the development and progression of the disease. Taking into consideration the genetic and molecular background, this review highlights the genetic role of inflammatory genes involved in AMD pathogenesis and progression.http://dx.doi.org/10.1155/2014/582842 |
| spellingShingle | Raffaella Cascella Michele Ragazzo Claudia Strafella Filippo Missiroli Paola Borgiani Francesco Angelucci Luigi Tonino Marsella Andrea Cusumano Giuseppe Novelli Federico Ricci Emiliano Giardina Age-Related Macular Degeneration: Insights into Inflammatory Genes Journal of Ophthalmology |
| title | Age-Related Macular Degeneration: Insights into Inflammatory Genes |
| title_full | Age-Related Macular Degeneration: Insights into Inflammatory Genes |
| title_fullStr | Age-Related Macular Degeneration: Insights into Inflammatory Genes |
| title_full_unstemmed | Age-Related Macular Degeneration: Insights into Inflammatory Genes |
| title_short | Age-Related Macular Degeneration: Insights into Inflammatory Genes |
| title_sort | age related macular degeneration insights into inflammatory genes |
| url | http://dx.doi.org/10.1155/2014/582842 |
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