Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy
Herbal medicine unswervingly serves human health by modernizing preparation and administration. Coronary artery atherosclerosis is a serious threat to human health and survival all over the world. Following experimental and clinical evidence, we collected four herbal treatments containing herbal str...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/6621925 |
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| _version_ | 1832550129338417152 |
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| author | Yu Cao Yang Liu Tian Zhang Wei Lei Boli Zhang |
| author_facet | Yu Cao Yang Liu Tian Zhang Wei Lei Boli Zhang |
| author_sort | Yu Cao |
| collection | DOAJ |
| description | Herbal medicine unswervingly serves human health by modernizing preparation and administration. Coronary artery atherosclerosis is a serious threat to human health and survival all over the world. Following experimental and clinical evidence, we collected four herbal treatments containing herbal strategy I (San Qi), II (Injectio Salvia Miltiorrhizae), III (Danhong injection), and IV (Taoren Honghua Jian granule) against coronary artery disease. In order to analyze their similarities and differences in controlling coronary artery atherosclerosis, we investigated each herb of four strategies and revealed that the number of active components and molecule targets is increasing with the herb category of herbal strategy. Nitric oxide-associated carbonate dehydratase activity and nitrogen metabolism are tacitly enriched by target corresponding genes with statistical significance in four strategies. The herbal strategy with multiherb not merely possesses more amounts and interactions of target proteins than the strategy with single-herb but also enlarges interaction partners of target proteins like PTPN11 and STAT3 in strategy II, III, and IV. Whereas single-herb also involves regulating network core proteins in consistent with compatibility, such as SRC and PIK3R1 that are mostly targeted by strategy I, III, and IV. Comparing the targets of the herbal strategies and three existing drugs (atenolol, pravastatin and propranolol) and the symbols of coronary artery atherosclerosis, we discovered that MAOA, HTR1A, and ABCG2 are overlapping in the three groups. Hence, our work enables people to better understand the connections and distinctions of single- and multiherb on the healing of coronary artery atherosclerosis. |
| format | Article |
| id | doaj-art-3950d5b4afbf4d7b868f40a369946441 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-3950d5b4afbf4d7b868f40a3699464412025-02-03T06:07:39ZengWileyCardiology Research and Practice2090-80162090-05972021-01-01202110.1155/2021/66219256621925Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis TherapyYu Cao0Yang Liu1Tian Zhang2Wei Lei3Boli Zhang4Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Tianjin 301617, ChinaSchool of Chemical Engineering and Technology, Tianjin University, No. 135 Yaguan Road, Tianjin 300350, ChinaState Key Laboratory of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Neinan Street, Beijing 100700, ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Tianjin 301617, ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Tianjin 301617, ChinaHerbal medicine unswervingly serves human health by modernizing preparation and administration. Coronary artery atherosclerosis is a serious threat to human health and survival all over the world. Following experimental and clinical evidence, we collected four herbal treatments containing herbal strategy I (San Qi), II (Injectio Salvia Miltiorrhizae), III (Danhong injection), and IV (Taoren Honghua Jian granule) against coronary artery disease. In order to analyze their similarities and differences in controlling coronary artery atherosclerosis, we investigated each herb of four strategies and revealed that the number of active components and molecule targets is increasing with the herb category of herbal strategy. Nitric oxide-associated carbonate dehydratase activity and nitrogen metabolism are tacitly enriched by target corresponding genes with statistical significance in four strategies. The herbal strategy with multiherb not merely possesses more amounts and interactions of target proteins than the strategy with single-herb but also enlarges interaction partners of target proteins like PTPN11 and STAT3 in strategy II, III, and IV. Whereas single-herb also involves regulating network core proteins in consistent with compatibility, such as SRC and PIK3R1 that are mostly targeted by strategy I, III, and IV. Comparing the targets of the herbal strategies and three existing drugs (atenolol, pravastatin and propranolol) and the symbols of coronary artery atherosclerosis, we discovered that MAOA, HTR1A, and ABCG2 are overlapping in the three groups. Hence, our work enables people to better understand the connections and distinctions of single- and multiherb on the healing of coronary artery atherosclerosis.http://dx.doi.org/10.1155/2021/6621925 |
| spellingShingle | Yu Cao Yang Liu Tian Zhang Wei Lei Boli Zhang Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy Cardiology Research and Practice |
| title | Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy |
| title_full | Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy |
| title_fullStr | Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy |
| title_full_unstemmed | Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy |
| title_short | Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy |
| title_sort | comparative analysis on single and multiherb strategies in coronary artery atherosclerosis therapy |
| url | http://dx.doi.org/10.1155/2021/6621925 |
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