The Role of Leukotriene Receptor Signaling in Inflammation and Cancer
Leukotrienes (LTs) and prostaglandins (PGs) are metabolites of arachidonic acid that play major roles in various inflammatory conditions. The release of these mediators, by cells recruited to or present at the site of inflammation, modulate/influence the magnitude of the inflammatory response. A bet...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.200 |
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| _version_ | 1832563074685468672 |
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| author | Ramin Massoumi Anita Sjölander |
| author_facet | Ramin Massoumi Anita Sjölander |
| author_sort | Ramin Massoumi |
| collection | DOAJ |
| description | Leukotrienes (LTs) and prostaglandins (PGs) are metabolites of arachidonic acid that play major roles in various inflammatory conditions. The release of these mediators, by cells recruited to or present at the site of inflammation, modulate/influence the magnitude of the inflammatory response. A better understanding of eicosanoids and how their receptors trigger intracellular signaling during inflammatory conditions is helping to elucidate the well-known connection between chronic inflammatory disease and neoplastic transformation. In the current review, we summarize the role of LTs and PGs in chronic inflammation and, in particular, we focus on recent insights into the role of CysLT1 receptor signaling pathway. In addition, we delineate how continuous CysLT1 receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity. |
| format | Article |
| id | doaj-art-3949d4aa95ea4493964184cd8c581a85 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-3949d4aa95ea4493964184cd8c581a852025-02-03T01:20:57ZengWileyThe Scientific World Journal1537-744X2007-01-0171413142110.1100/tsw.2007.200The Role of Leukotriene Receptor Signaling in Inflammation and CancerRamin Massoumi0Anita Sjölander1Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE-205 02 Malmo, SwedenCell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE-205 02 Malmo, SwedenLeukotrienes (LTs) and prostaglandins (PGs) are metabolites of arachidonic acid that play major roles in various inflammatory conditions. The release of these mediators, by cells recruited to or present at the site of inflammation, modulate/influence the magnitude of the inflammatory response. A better understanding of eicosanoids and how their receptors trigger intracellular signaling during inflammatory conditions is helping to elucidate the well-known connection between chronic inflammatory disease and neoplastic transformation. In the current review, we summarize the role of LTs and PGs in chronic inflammation and, in particular, we focus on recent insights into the role of CysLT1 receptor signaling pathway. In addition, we delineate how continuous CysLT1 receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity.http://dx.doi.org/10.1100/tsw.2007.200 |
| spellingShingle | Ramin Massoumi Anita Sjölander The Role of Leukotriene Receptor Signaling in Inflammation and Cancer The Scientific World Journal |
| title | The Role of Leukotriene Receptor Signaling in Inflammation and Cancer |
| title_full | The Role of Leukotriene Receptor Signaling in Inflammation and Cancer |
| title_fullStr | The Role of Leukotriene Receptor Signaling in Inflammation and Cancer |
| title_full_unstemmed | The Role of Leukotriene Receptor Signaling in Inflammation and Cancer |
| title_short | The Role of Leukotriene Receptor Signaling in Inflammation and Cancer |
| title_sort | role of leukotriene receptor signaling in inflammation and cancer |
| url | http://dx.doi.org/10.1100/tsw.2007.200 |
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