Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients
As novel biomarkers for gastroenteropancreatic neuroendocrine tumors (GEPNET) are in demand, we aimed to validate the clinical value of the NETest in Japanese patients. Between 2021 and 2023, blood and clinical data were collected from patients with GEPNET. Among 35 patients (median age: 59 [49–66]...
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| Format: | Article |
| Language: | English |
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The Japan Endocrine Society
2024-09-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/9/71_EJ24-0090/_html/-char/en |
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| author | Hao Zhang Takahiro Tsuchikawa Satoshi Takeuchi Kenji Hirata Kimitaka Tanaka Aya Matsui Yoshitsugu Nakanishi Toshimichi Asano Takehiro Noji Toru Nakamura Shintaro Takeuchi Masataka Wada Satoshi Hirano |
| author_facet | Hao Zhang Takahiro Tsuchikawa Satoshi Takeuchi Kenji Hirata Kimitaka Tanaka Aya Matsui Yoshitsugu Nakanishi Toshimichi Asano Takehiro Noji Toru Nakamura Shintaro Takeuchi Masataka Wada Satoshi Hirano |
| author_sort | Hao Zhang |
| collection | DOAJ |
| description | As novel biomarkers for gastroenteropancreatic neuroendocrine tumors (GEPNET) are in demand, we aimed to validate the clinical value of the NETest in Japanese patients. Between 2021 and 2023, blood and clinical data were collected from patients with GEPNET. Among 35 patients (median age: 59 [49–66] years), 27 cases originated from the pancreas and eight from the gastrointestinal tract. Of 69 samples sent to the laboratory, 56 (81.2%) underwent NETest. The diagnostic sensitivity was 97.1%. Among three patients who underwent R0 resection and four treated with peptide receptor radionuclide therapy, the changes in NETest scores closely correlated with disease progression. The NETest demonstrated high diagnostic efficacy and accurate therapeutic monitoring capabilities in a Japanese population. |
| format | Article |
| id | doaj-art-39465c1aa9dc4078afadaefabe35b0aa |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-39465c1aa9dc4078afadaefabe35b0aa2025-01-22T05:20:11ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-09-0171987388010.1507/endocrj.EJ24-0090endocrjInitial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patientsHao Zhang0Takahiro Tsuchikawa1Satoshi Takeuchi2Kenji Hirata3Kimitaka Tanaka4Aya Matsui5Yoshitsugu Nakanishi6Toshimichi Asano7Takehiro Noji8Toru Nakamura9Shintaro Takeuchi10Masataka Wada11Satoshi Hirano12Department of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, ChinaDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo 060-8638, JapanDepartment of Medical Oncology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDepartment of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo 060-8638, JapanDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo 060-8638, JapanDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo 060-8638, JapanDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo 060-8638, JapanDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo 060-8638, JapanDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo 060-8638, JapanDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo 060-8638, JapanDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo 060-8638, JapanDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo 060-8638, JapanAs novel biomarkers for gastroenteropancreatic neuroendocrine tumors (GEPNET) are in demand, we aimed to validate the clinical value of the NETest in Japanese patients. Between 2021 and 2023, blood and clinical data were collected from patients with GEPNET. Among 35 patients (median age: 59 [49–66] years), 27 cases originated from the pancreas and eight from the gastrointestinal tract. Of 69 samples sent to the laboratory, 56 (81.2%) underwent NETest. The diagnostic sensitivity was 97.1%. Among three patients who underwent R0 resection and four treated with peptide receptor radionuclide therapy, the changes in NETest scores closely correlated with disease progression. The NETest demonstrated high diagnostic efficacy and accurate therapeutic monitoring capabilities in a Japanese population.https://www.jstage.jst.go.jp/article/endocrj/71/9/71_EJ24-0090/_html/-char/engastroenteropancreatic neuroendocrine tumornetestjapanese populationapplication valuepeptide receptor radionuclide therapy |
| spellingShingle | Hao Zhang Takahiro Tsuchikawa Satoshi Takeuchi Kenji Hirata Kimitaka Tanaka Aya Matsui Yoshitsugu Nakanishi Toshimichi Asano Takehiro Noji Toru Nakamura Shintaro Takeuchi Masataka Wada Satoshi Hirano Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients Endocrine Journal gastroenteropancreatic neuroendocrine tumor netest japanese population application value peptide receptor radionuclide therapy |
| title | Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients |
| title_full | Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients |
| title_fullStr | Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients |
| title_full_unstemmed | Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients |
| title_short | Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients |
| title_sort | initial validation of the clinical significance of the netest in japanese gastroenteropancreatic neuroendocrine tumor patients |
| topic | gastroenteropancreatic neuroendocrine tumor netest japanese population application value peptide receptor radionuclide therapy |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/9/71_EJ24-0090/_html/-char/en |
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