Isolated Langerhans Cell Histiocytosis of Orbit: A Case Report and Review of the Literature
A 2-year-old male child presented with a painless progressive mass in the inferolateral aspect of right orbit of three-month duration. Differential leucocyte count revealed raised eosinophil count (13%). On radiological examination, CT scan showed 25 × 27 mm round well-defined smooth-outlined homoge...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Ophthalmological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/1529281 |
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| author | Mayuresh Naik Anuj Mehta Neha Mehrotra Anil Solanki |
| author_facet | Mayuresh Naik Anuj Mehta Neha Mehrotra Anil Solanki |
| author_sort | Mayuresh Naik |
| collection | DOAJ |
| description | A 2-year-old male child presented with a painless progressive mass in the inferolateral aspect of right orbit of three-month duration. Differential leucocyte count revealed raised eosinophil count (13%). On radiological examination, CT scan showed 25 × 27 mm round well-defined smooth-outlined homogenously enhancing extraconal mass arising from the zygomatic bone at the inferotemporal periorbital area of right orbit with bone erosion. Histopathological examination of the incision biopsy revealed characteristic Langerhans cells and immunohistochemical studies were positive for S-100 protein and adenosine deaminase. A diagnosis of Langerhans Cell Histiocytosis (LCH) was made and PET-CT revealed no other foci of uptake anywhere else in the body. The patient received 12 cycles of vinblastine, 0.2 mg/kg body weight, along with oral prednisolone, 1 mg/kg body weight. On completion of three cycles of chemotherapy, a reduction in size of the mass was noticed. A repeat PET scan was done 3 months after completion of chemotherapy did not reveal any activity noted previously. |
| format | Article |
| id | doaj-art-3941adaa478147a283903e4cfb80cc9f |
| institution | Kabale University |
| issn | 2090-6722 2090-6730 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Ophthalmological Medicine |
| spelling | doaj-art-3941adaa478147a283903e4cfb80cc9f2025-02-03T06:00:54ZengWileyCase Reports in Ophthalmological Medicine2090-67222090-67302018-01-01201810.1155/2018/15292811529281Isolated Langerhans Cell Histiocytosis of Orbit: A Case Report and Review of the LiteratureMayuresh Naik0Anuj Mehta1Neha Mehrotra2Anil Solanki3Department of Ophthalmology, VMMC & Safdarjung Hospital, Ring Road, Ansari Nagar, New Delhi 110029, IndiaDepartment of Ophthalmology, VMMC & Safdarjung Hospital, Ring Road, Ansari Nagar, New Delhi 110029, IndiaDepartment of Ophthalmology, VMMC & Safdarjung Hospital, Ring Road, Ansari Nagar, New Delhi 110029, IndiaDepartment of Ophthalmology, VMMC & Safdarjung Hospital, Ring Road, Ansari Nagar, New Delhi 110029, IndiaA 2-year-old male child presented with a painless progressive mass in the inferolateral aspect of right orbit of three-month duration. Differential leucocyte count revealed raised eosinophil count (13%). On radiological examination, CT scan showed 25 × 27 mm round well-defined smooth-outlined homogenously enhancing extraconal mass arising from the zygomatic bone at the inferotemporal periorbital area of right orbit with bone erosion. Histopathological examination of the incision biopsy revealed characteristic Langerhans cells and immunohistochemical studies were positive for S-100 protein and adenosine deaminase. A diagnosis of Langerhans Cell Histiocytosis (LCH) was made and PET-CT revealed no other foci of uptake anywhere else in the body. The patient received 12 cycles of vinblastine, 0.2 mg/kg body weight, along with oral prednisolone, 1 mg/kg body weight. On completion of three cycles of chemotherapy, a reduction in size of the mass was noticed. A repeat PET scan was done 3 months after completion of chemotherapy did not reveal any activity noted previously.http://dx.doi.org/10.1155/2018/1529281 |
| spellingShingle | Mayuresh Naik Anuj Mehta Neha Mehrotra Anil Solanki Isolated Langerhans Cell Histiocytosis of Orbit: A Case Report and Review of the Literature Case Reports in Ophthalmological Medicine |
| title | Isolated Langerhans Cell Histiocytosis of Orbit: A Case Report and Review of the Literature |
| title_full | Isolated Langerhans Cell Histiocytosis of Orbit: A Case Report and Review of the Literature |
| title_fullStr | Isolated Langerhans Cell Histiocytosis of Orbit: A Case Report and Review of the Literature |
| title_full_unstemmed | Isolated Langerhans Cell Histiocytosis of Orbit: A Case Report and Review of the Literature |
| title_short | Isolated Langerhans Cell Histiocytosis of Orbit: A Case Report and Review of the Literature |
| title_sort | isolated langerhans cell histiocytosis of orbit a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2018/1529281 |
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