Cord blood T regulatory cells synergize with ruxolitinib to improve GVHD outcomes

Cord blood T regulatory cells synergize with ruxolitinib to improve GVHD outcomes

BackgroundAdoptive therapy with umbilical cord blood (UCB) T-regulatory (Treg) cells can prevent graft vs. host disease (GVHD). We hypothesize that UCB Tregs can treat GVHD and synergize with ruxolitinib, Jak2 inhibitor, to improve outcomes.MethodsUCB Treg potency and efficacy was examined using cel...

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Bibliographic Details
Main Authors: Ke Zeng, Hongbing Ma, Meixian Huang, Mi-Ae Lyu, Tara Sadeghi, Christopher R. Flowers, Simrit Parmar
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Transplantation
Subjects:
GVHD
T regulatory cell
allogeneic
cord blood
ruxolitinib
Online Access:https://www.frontiersin.org/articles/10.3389/frtra.2024.1448650/full
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