Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease
The global incidence and mortality rates of alcohol-related liver disease are on the rise, reflecting a growing health concern worldwide. Alcohol-related liver disease develops due to a complex interplay of multiple reasons, including oxidative stress generated during the metabolism of ethanol, immu...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/74 |
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| author | Wei Li Wenkang Gao Shengqi Yan Ling Yang Qingjing Zhu Huikuan Chu |
| author_facet | Wei Li Wenkang Gao Shengqi Yan Ling Yang Qingjing Zhu Huikuan Chu |
| author_sort | Wei Li |
| collection | DOAJ |
| description | The global incidence and mortality rates of alcohol-related liver disease are on the rise, reflecting a growing health concern worldwide. Alcohol-related liver disease develops due to a complex interplay of multiple reasons, including oxidative stress generated during the metabolism of ethanol, immune response activated by immunogenic substances, and subsequent inflammatory processes. Recent research highlights the gut microbiota’s significant role in the progression of alcohol-related liver disease. In patients with alcohol-related liver disease, the relative abundance of pathogenic bacteria, including <i>Enterococcus faecalis</i>, increases and is positively correlated with the level of severity exhibited by alcohol-related liver disease. Supplement probiotics like <i>Lactobacillus</i>, as well as <i>Bifidobacterium</i>, have been found to alleviate alcohol-related liver disease. The gut microbiota is speculated to trigger specific signaling pathways, influence metabolite profiles, and modulate immune responses in the gut and liver. This research aimed to investigate the role of gut microorganisms in the onset and advancement of alcohol-related liver disease, as well as to uncover the underlying mechanisms by which the gut microbiota may contribute to its development. This review outlines current treatments for reversing gut dysbiosis, including probiotics, fecal microbiota transplantation, and targeted phage therapy. Particularly, targeted therapy will be a vital aspect of future alcohol-related liver disease treatment. It is to be hoped that this article will prove beneficial for the treatment of alcohol-related liver disease. |
| format | Article |
| id | doaj-art-3932d5eea90749e1834505eae93f6425 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-3932d5eea90749e1834505eae93f64252025-01-24T13:23:55ZengMDPI AGBiomedicines2227-90592024-12-011317410.3390/biomedicines13010074Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver DiseaseWei Li0Wenkang Gao1Shengqi Yan2Ling Yang3Qingjing Zhu4Huikuan Chu5Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Hubei Clinical Research Center for Infectious Diseases, Wuhan Research Center for Communicable Disease Diagnosis and Treatment, Chinese Academy of Medical Sciences, Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academy of Sciences, Wuhan 430023, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaWuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Hubei Clinical Research Center for Infectious Diseases, Wuhan Research Center for Communicable Disease Diagnosis and Treatment, Chinese Academy of Medical Sciences, Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academy of Sciences, Wuhan 430023, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaThe global incidence and mortality rates of alcohol-related liver disease are on the rise, reflecting a growing health concern worldwide. Alcohol-related liver disease develops due to a complex interplay of multiple reasons, including oxidative stress generated during the metabolism of ethanol, immune response activated by immunogenic substances, and subsequent inflammatory processes. Recent research highlights the gut microbiota’s significant role in the progression of alcohol-related liver disease. In patients with alcohol-related liver disease, the relative abundance of pathogenic bacteria, including <i>Enterococcus faecalis</i>, increases and is positively correlated with the level of severity exhibited by alcohol-related liver disease. Supplement probiotics like <i>Lactobacillus</i>, as well as <i>Bifidobacterium</i>, have been found to alleviate alcohol-related liver disease. The gut microbiota is speculated to trigger specific signaling pathways, influence metabolite profiles, and modulate immune responses in the gut and liver. This research aimed to investigate the role of gut microorganisms in the onset and advancement of alcohol-related liver disease, as well as to uncover the underlying mechanisms by which the gut microbiota may contribute to its development. This review outlines current treatments for reversing gut dysbiosis, including probiotics, fecal microbiota transplantation, and targeted phage therapy. Particularly, targeted therapy will be a vital aspect of future alcohol-related liver disease treatment. It is to be hoped that this article will prove beneficial for the treatment of alcohol-related liver disease.https://www.mdpi.com/2227-9059/13/1/74alcohol-related liver diseasegut microbiotagut microbiota metabolitesintestinal barriergut–liver axisinflammatory response |
| spellingShingle | Wei Li Wenkang Gao Shengqi Yan Ling Yang Qingjing Zhu Huikuan Chu Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease Biomedicines alcohol-related liver disease gut microbiota gut microbiota metabolites intestinal barrier gut–liver axis inflammatory response |
| title | Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease |
| title_full | Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease |
| title_fullStr | Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease |
| title_full_unstemmed | Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease |
| title_short | Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease |
| title_sort | gut microbiota as emerging players in the development of alcohol related liver disease |
| topic | alcohol-related liver disease gut microbiota gut microbiota metabolites intestinal barrier gut–liver axis inflammatory response |
| url | https://www.mdpi.com/2227-9059/13/1/74 |
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