Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study
Background: Mushrooms are a good source of many nutrients which are potentially beneficial for chronic diseases. We speculated that due to its abundant nutrients edible mushrooms might have a beneficial effect on the prevention of subclinical thyroid dysfunction (SCTD). Therefore, we designed a larg...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022001264 |
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| author | Juanjuan Zhang Sabina Rayamajhi Amrish Thapa Ge Meng Qing Zhang Li Liu Hongmei Wu Yeqing Gu Shunming Zhang Tingjing Zhang Xuena Wang Zhixia Cao Jun Dong Xiaoxi Zheng Xu Zhang Xinrong Dong Xing Wang Shaomei Sun Ming Zhou Qiyu Jia Kun Song Kaijun Niu |
| author_facet | Juanjuan Zhang Sabina Rayamajhi Amrish Thapa Ge Meng Qing Zhang Li Liu Hongmei Wu Yeqing Gu Shunming Zhang Tingjing Zhang Xuena Wang Zhixia Cao Jun Dong Xiaoxi Zheng Xu Zhang Xinrong Dong Xing Wang Shaomei Sun Ming Zhou Qiyu Jia Kun Song Kaijun Niu |
| author_sort | Juanjuan Zhang |
| collection | DOAJ |
| description | Background: Mushrooms are a good source of many nutrients which are potentially beneficial for chronic diseases. We speculated that due to its abundant nutrients edible mushrooms might have a beneficial effect on the prevention of subclinical thyroid dysfunction (SCTD). Therefore, we designed a large-scale cohort study to examine whether mushrooms consumption is a protective factor for SCTD in adults. Methods: This prospective cohort study investigated 6631 participants (mean age: (45.0 ± 10.2) years; 55.1 % men). Edible mushrooms consumption was measured at baseline using a validated food frequency questionnaire. SCTD was defined as abnormal serum thyroid-stimulating hormone levels and normal free thyroxine. Cox proportional hazards regression models were used to examine the association of edible mushrooms consumption with incident SCTD. Results: During follow-up period, a total of 262 new cases of SCTD were identified, the incidence rate of subclinical hypothyroidism was 8.9/1000 person-years and subclinical hyperthyroidism was 7.2/1000 person-years. After adjusting potential confounding factors, the multivariable hazard ratios (95 % confidence intervals) for subclinical hypothyroidism were 1.00 (reference) for almost never, 0.53 (0.29, 0.97) for 1–3 times/week and 0.30 (0.10, 0.87) for ≥ 4 times/week (P for trend = 0.02). It also showed edible mushrooms consumption was inversely associated with subclinical hypothyroidism in obese individuals but not non-obese individuals, the final hazard ratios (95 % confidence intervals) were 0.14 (0.03, 0.73) (P for trend < 0.01). Conclusions: his population-based prospective cohort study has firstly demonstrated that higher edible mushrooms consumption was significantly associated with lower incidence of subclinical hypothyroidism among general adult population, especially in obese individuals. |
| format | Article |
| id | doaj-art-392b762b6ae7492da139b344a84b0fc4 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-392b762b6ae7492da139b344a84b0fc42025-02-03T05:15:36ZengTsinghua University PressFood Science and Human Wellness2213-45302023-01-01121295302Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort studyJuanjuan Zhang0Sabina Rayamajhi1Amrish Thapa2Ge Meng3Qing Zhang4Li Liu5Hongmei Wu6Yeqing Gu7Shunming Zhang8Tingjing Zhang9Xuena Wang10Zhixia Cao11Jun Dong12Xiaoxi Zheng13Xu Zhang14Xinrong Dong15Xing Wang16Shaomei Sun17Ming Zhou18Qiyu Jia19Kun Song20Kaijun Niu21Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, China; Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaHealth Management Centre, Tianjin Medical University General Hospital, Tianjin 300070, ChinaHealth Management Centre, Tianjin Medical University General Hospital, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaNutrition and Radiation Epidemiology Research Center, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaHealth Management Centre, Tianjin Medical University General Hospital, Tianjin 300070, ChinaHealth Management Centre, Tianjin Medical University General Hospital, Tianjin 300070, ChinaHealth Management Centre, Tianjin Medical University General Hospital, Tianjin 300070, ChinaHealth Management Centre, Tianjin Medical University General Hospital, Tianjin 300070, ChinaHealth Management Centre, Tianjin Medical University General Hospital, Tianjin 300070, ChinaNutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, China; Health Management Centre, Tianjin Medical University General Hospital, Tianjin 300070, China; Nutrition and Radiation Epidemiology Research Center, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China; Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China; Corresponding author at: Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin 300070, China.Background: Mushrooms are a good source of many nutrients which are potentially beneficial for chronic diseases. We speculated that due to its abundant nutrients edible mushrooms might have a beneficial effect on the prevention of subclinical thyroid dysfunction (SCTD). Therefore, we designed a large-scale cohort study to examine whether mushrooms consumption is a protective factor for SCTD in adults. Methods: This prospective cohort study investigated 6631 participants (mean age: (45.0 ± 10.2) years; 55.1 % men). Edible mushrooms consumption was measured at baseline using a validated food frequency questionnaire. SCTD was defined as abnormal serum thyroid-stimulating hormone levels and normal free thyroxine. Cox proportional hazards regression models were used to examine the association of edible mushrooms consumption with incident SCTD. Results: During follow-up period, a total of 262 new cases of SCTD were identified, the incidence rate of subclinical hypothyroidism was 8.9/1000 person-years and subclinical hyperthyroidism was 7.2/1000 person-years. After adjusting potential confounding factors, the multivariable hazard ratios (95 % confidence intervals) for subclinical hypothyroidism were 1.00 (reference) for almost never, 0.53 (0.29, 0.97) for 1–3 times/week and 0.30 (0.10, 0.87) for ≥ 4 times/week (P for trend = 0.02). It also showed edible mushrooms consumption was inversely associated with subclinical hypothyroidism in obese individuals but not non-obese individuals, the final hazard ratios (95 % confidence intervals) were 0.14 (0.03, 0.73) (P for trend < 0.01). Conclusions: his population-based prospective cohort study has firstly demonstrated that higher edible mushrooms consumption was significantly associated with lower incidence of subclinical hypothyroidism among general adult population, especially in obese individuals.http://www.sciencedirect.com/science/article/pii/S2213453022001264Edible mushroomsSubclinical thyroid dysfunctionObese individualsCohort study |
| spellingShingle | Juanjuan Zhang Sabina Rayamajhi Amrish Thapa Ge Meng Qing Zhang Li Liu Hongmei Wu Yeqing Gu Shunming Zhang Tingjing Zhang Xuena Wang Zhixia Cao Jun Dong Xiaoxi Zheng Xu Zhang Xinrong Dong Xing Wang Shaomei Sun Ming Zhou Qiyu Jia Kun Song Kaijun Niu Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study Food Science and Human Wellness Edible mushrooms Subclinical thyroid dysfunction Obese individuals Cohort study |
| title | Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study |
| title_full | Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study |
| title_fullStr | Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study |
| title_full_unstemmed | Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study |
| title_short | Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study |
| title_sort | edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults especially in obese individuals a prospective cohort study |
| topic | Edible mushrooms Subclinical thyroid dysfunction Obese individuals Cohort study |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022001264 |
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