CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS
Expression of Toll-like receptors (TLRs) on myeloid cells is of key importance for induction of systemic reactions caused by bacterial damage, and activation mechanisms of innate immune response. The study included thirty-six patients with sepsis in whom we assessed a prognostic value of TLR2, TLR4,...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2015-06-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/886 |
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| author | V. A. Lazanovich E. V. Markelova G. A. Smirnov T. P. Smolina |
| author_facet | V. A. Lazanovich E. V. Markelova G. A. Smirnov T. P. Smolina |
| author_sort | V. A. Lazanovich |
| collection | DOAJ |
| description | Expression of Toll-like receptors (TLRs) on myeloid cells is of key importance for induction of systemic reactions caused by bacterial damage, and activation mechanisms of innate immune response. The study included thirty-six patients with sepsis in whom we assessed a prognostic value of TLR2, TLR4, CD14, HLA-DR expressed on monocytes, depending on severity of the disease and clinical outcomes. There were neither significant differences in TLR4 expression at all stages of clinical observation, nor correlations between expression of this marker on monocytes and severity of the disease, or outcomes of septic conditions. Low levels of MFI on monocytes TLR2, HLA-DR at 5 and 10 days, like as decreased expression of CD14 on 10th day of the disease were shown to be predictive for poor clinical outcomes of sepsis. |
| format | Article |
| id | doaj-art-391ffc98583b49f3bcc33354ac1ce1f0 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2015-06-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-391ffc98583b49f3bcc33354ac1ce1f02025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2015-06-0117322122810.15789/1563-0625-2015-3-221-228778CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSISV. A. Lazanovich0E. V. Markelova1G. A. Smirnov2T. P. Smolina3Pacific State Medical University, VladivostokPacific State Medical University, VladivostokPacific State Medical University, VladivostokG.P. Somov Research Institute of Epidemiology and Microbiology, Siberian Branch of Russian Academy of Medical Sciences, VladivostokExpression of Toll-like receptors (TLRs) on myeloid cells is of key importance for induction of systemic reactions caused by bacterial damage, and activation mechanisms of innate immune response. The study included thirty-six patients with sepsis in whom we assessed a prognostic value of TLR2, TLR4, CD14, HLA-DR expressed on monocytes, depending on severity of the disease and clinical outcomes. There were neither significant differences in TLR4 expression at all stages of clinical observation, nor correlations between expression of this marker on monocytes and severity of the disease, or outcomes of septic conditions. Low levels of MFI on monocytes TLR2, HLA-DR at 5 and 10 days, like as decreased expression of CD14 on 10th day of the disease were shown to be predictive for poor clinical outcomes of sepsis.https://www.mimmun.ru/mimmun/article/view/886toll-like receptorsmonocytessepsis |
| spellingShingle | V. A. Lazanovich E. V. Markelova G. A. Smirnov T. P. Smolina CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS Медицинская иммунология toll-like receptors monocytes sepsis |
| title | CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS |
| title_full | CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS |
| title_fullStr | CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS |
| title_full_unstemmed | CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS |
| title_short | CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS |
| title_sort | clinical significance of toll2 toll4 cd14 and hla dr expression on the monocytes in patients with sepsis |
| topic | toll-like receptors monocytes sepsis |
| url | https://www.mimmun.ru/mimmun/article/view/886 |
| work_keys_str_mv | AT valazanovich clinicalsignificanceoftoll2toll4cd14andhladrexpressiononthemonocytesinpatientswithsepsis AT evmarkelova clinicalsignificanceoftoll2toll4cd14andhladrexpressiononthemonocytesinpatientswithsepsis AT gasmirnov clinicalsignificanceoftoll2toll4cd14andhladrexpressiononthemonocytesinpatientswithsepsis AT tpsmolina clinicalsignificanceoftoll2toll4cd14andhladrexpressiononthemonocytesinpatientswithsepsis |