β-alanine spectrophotometric determination in reaction with sodium salt of 1,2-naphthoquinone-4-sulfonic acid
Aim. The new spectrophotometric method for the quantitative determination of β-alanine in pharmaceutical formulations has been developed. Methods and results. This method is based on the measurement of aqueous β-alanine solutions absorption at 470 nm. The proposed method is actual according to th...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Zaporizhzhia State Medical and Pharmaceutical University
2015-02-01
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| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/39870/36001 |
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| Summary: | Aim. The new spectrophotometric method for the quantitative determination of β-alanine in pharmaceutical formulations has been developed.
Methods and results. This method is based on the measurement of aqueous β-alanine solutions absorption at 470 nm. The proposed method is actual according to the validation requirements of Ukrainian Pharmacopeia. The analytical method was optimized and validated by establishing the linearity (the correlation coefficient r = 1,000), precision (RSD% = 0,806, n = 9) and the accuracy ( = 100,8 %).
Conclusion. According to the experimental data, the technique can be correctly reproduced and it is suitable for using in laboratories of the State Inspection for Quality Control of Medicines and QCD of the chemical-pharmaceutical enterprises. |
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| ISSN: | 2306-4145 2310-1210 |