From diagnosis to treatment: exploring the mechanisms underlying optic neuritis in multiple sclerosis
Abstract Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, commonly causing sensory disturbances, motor weakness, impaired gait, incoordination and optic neuritis (ON). According to the statistics, up to 50% of MS patients experience vision problems during...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06105-1 |
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| author | Bin Tong Xin Zhang Haijian Hu Huayi Yang Xifeng Wang Maolin Zhong Fan Yang Fuzhou Hua |
| author_facet | Bin Tong Xin Zhang Haijian Hu Huayi Yang Xifeng Wang Maolin Zhong Fan Yang Fuzhou Hua |
| author_sort | Bin Tong |
| collection | DOAJ |
| description | Abstract Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, commonly causing sensory disturbances, motor weakness, impaired gait, incoordination and optic neuritis (ON). According to the statistics, up to 50% of MS patients experience vision problems during the disease course, suffering from blurred vision, pain, color vision deficits, and even blindness. Treatments have progressed from corticosteroids to therapies targeted against B/T cells. This review comprehensively and systematically reappraises the diagnostic methods for visual impairment in MS patients. It also summarizes the most recent treatment approaches and effective medications for ON in MS. Finally, we examine the immunoinflammatory mechanisms that underlie lesions in the central nervous system in multiple sclerosis, in order to direct future investigations to confirm these mechanisms in the visual pathway. |
| format | Article |
| id | doaj-art-38ffcc9c495240f588446efc91b71854 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-38ffcc9c495240f588446efc91b718542025-01-26T12:50:21ZengBMCJournal of Translational Medicine1479-58762025-01-0123112010.1186/s12967-025-06105-1From diagnosis to treatment: exploring the mechanisms underlying optic neuritis in multiple sclerosisBin Tong0Xin Zhang1Haijian Hu2Huayi Yang3Xifeng Wang4Maolin Zhong5Fan Yang6Fuzhou Hua7Department of Anesthesiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Anesthesiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Ophthalmology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityNanchang Medical CollegeDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Gannan Medical UniversityDepartment of Cardiothoracic Surgery, People’s Hospital of Ruijin CityDepartment of Anesthesiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityAbstract Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, commonly causing sensory disturbances, motor weakness, impaired gait, incoordination and optic neuritis (ON). According to the statistics, up to 50% of MS patients experience vision problems during the disease course, suffering from blurred vision, pain, color vision deficits, and even blindness. Treatments have progressed from corticosteroids to therapies targeted against B/T cells. This review comprehensively and systematically reappraises the diagnostic methods for visual impairment in MS patients. It also summarizes the most recent treatment approaches and effective medications for ON in MS. Finally, we examine the immunoinflammatory mechanisms that underlie lesions in the central nervous system in multiple sclerosis, in order to direct future investigations to confirm these mechanisms in the visual pathway.https://doi.org/10.1186/s12967-025-06105-1Multiple sclerosisOptic neuritisVisual impairmentDiagnosisTherapyMechanism |
| spellingShingle | Bin Tong Xin Zhang Haijian Hu Huayi Yang Xifeng Wang Maolin Zhong Fan Yang Fuzhou Hua From diagnosis to treatment: exploring the mechanisms underlying optic neuritis in multiple sclerosis Journal of Translational Medicine Multiple sclerosis Optic neuritis Visual impairment Diagnosis Therapy Mechanism |
| title | From diagnosis to treatment: exploring the mechanisms underlying optic neuritis in multiple sclerosis |
| title_full | From diagnosis to treatment: exploring the mechanisms underlying optic neuritis in multiple sclerosis |
| title_fullStr | From diagnosis to treatment: exploring the mechanisms underlying optic neuritis in multiple sclerosis |
| title_full_unstemmed | From diagnosis to treatment: exploring the mechanisms underlying optic neuritis in multiple sclerosis |
| title_short | From diagnosis to treatment: exploring the mechanisms underlying optic neuritis in multiple sclerosis |
| title_sort | from diagnosis to treatment exploring the mechanisms underlying optic neuritis in multiple sclerosis |
| topic | Multiple sclerosis Optic neuritis Visual impairment Diagnosis Therapy Mechanism |
| url | https://doi.org/10.1186/s12967-025-06105-1 |
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