Burden of Myasthenia Gravis in the Czech Republic: Analysis of the Nationwide Patient Registry
Abstract Introduction The main goal of this study was to describe the Czech population of patients with MG in terms of demographics, disease characteristics, management approaches, and treatment trends. Methods We selected all patients, both incident and prevalent, who were enrolled in the Czech MyR...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-12-01
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| Series: | Neurology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40120-024-00682-x |
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| author | Stanislav Voháňka Aleš Tichopád Magda Horáková Jana Junkerová Michala Jakubíková Jiří Piťha Michaela Týblová Daniela Vlažná Katarína Breciková Jacek Cudny Petr Hájek |
| author_facet | Stanislav Voháňka Aleš Tichopád Magda Horáková Jana Junkerová Michala Jakubíková Jiří Piťha Michaela Týblová Daniela Vlažná Katarína Breciková Jacek Cudny Petr Hájek |
| author_sort | Stanislav Voháňka |
| collection | DOAJ |
| description | Abstract Introduction The main goal of this study was to describe the Czech population of patients with MG in terms of demographics, disease characteristics, management approaches, and treatment trends. Methods We selected all patients, both incident and prevalent, who were enrolled in the Czech MyReg registry between August 24, 2015 and November 19, 2021. For the descriptive analysis, all patients enrolled in the registry, regardless of their date of diagnosis or date of enrolment, were included. We analyzed the following disease-related endpoints: myasthenia gravis composite (MGC) score, forced vital capacity (FVC), and Myasthenia Gravis Foundation of America (MGFA) clinical classification. Results The incidence showed a consistent increasing trend from 0.62 to 3.13. The mean MGC score was 5.0 (median 4.0, 95% CI 4.7, 5.3) representing mild form of MG. The difference in FVC from the predicted value in patients during and without myasthenic crisis was 58.93% (95% CI 37.27, 80.59) and 75.93% (95% CI 74.87, 77.00), respectively. We identified 70 patients (5.0%) with refractory MG, of whom 58.6% were female. The MGFA classifications in those with refractory vs. non-refractory disease was as follows: IIa 21.8% vs 23.2%, IIb 45.3% vs 33.6%, and IIIb 14.1% vs 4.6%, respectively. Conclusion Our analysis shows that the incidence of MG is increasing in the Czech Republic and that patients with refractory disease, of whom up to 58% are female, have a higher burden of disease than non-refractory patients. |
| format | Article |
| id | doaj-art-38fcead6196045bb907e786d184a2a49 |
| institution | Kabale University |
| issn | 2193-8253 2193-6536 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Neurology and Therapy |
| spelling | doaj-art-38fcead6196045bb907e786d184a2a492025-01-26T12:58:36ZengAdis, Springer HealthcareNeurology and Therapy2193-82532193-65362024-12-0114122724210.1007/s40120-024-00682-xBurden of Myasthenia Gravis in the Czech Republic: Analysis of the Nationwide Patient RegistryStanislav Voháňka0Aleš Tichopád1Magda Horáková2Jana Junkerová3Michala Jakubíková4Jiří Piťha5Michaela Týblová6Daniela Vlažná7Katarína Breciková8Jacek Cudny9Petr Hájek10Department of Neurology, Neuromuscular Centre, University Hospital BrnoDepartment of Biomedical Technology, Czech Technical University in PragueDepartment of Neurology, Neuromuscular Centre, University Hospital BrnoDepartment of Neurology, University HospitalDepartment of Neurology and Center for Clinical Neuroscience, First Faculty of Medicine and General University Hospital, Charles University in PragueDepartment of Neurology and Center for Clinical Neuroscience, First Faculty of Medicine and General University Hospital, Charles University in PragueDepartment of Neurology and Center for Clinical Neuroscience, First Faculty of Medicine and General University Hospital, Charles University in PragueDepartment of Neurology, Neuromuscular Centre, University Hospital BrnoCEEOR S.R.O.UCB PharmaUCB PharmaAbstract Introduction The main goal of this study was to describe the Czech population of patients with MG in terms of demographics, disease characteristics, management approaches, and treatment trends. Methods We selected all patients, both incident and prevalent, who were enrolled in the Czech MyReg registry between August 24, 2015 and November 19, 2021. For the descriptive analysis, all patients enrolled in the registry, regardless of their date of diagnosis or date of enrolment, were included. We analyzed the following disease-related endpoints: myasthenia gravis composite (MGC) score, forced vital capacity (FVC), and Myasthenia Gravis Foundation of America (MGFA) clinical classification. Results The incidence showed a consistent increasing trend from 0.62 to 3.13. The mean MGC score was 5.0 (median 4.0, 95% CI 4.7, 5.3) representing mild form of MG. The difference in FVC from the predicted value in patients during and without myasthenic crisis was 58.93% (95% CI 37.27, 80.59) and 75.93% (95% CI 74.87, 77.00), respectively. We identified 70 patients (5.0%) with refractory MG, of whom 58.6% were female. The MGFA classifications in those with refractory vs. non-refractory disease was as follows: IIa 21.8% vs 23.2%, IIb 45.3% vs 33.6%, and IIIb 14.1% vs 4.6%, respectively. Conclusion Our analysis shows that the incidence of MG is increasing in the Czech Republic and that patients with refractory disease, of whom up to 58% are female, have a higher burden of disease than non-refractory patients.https://doi.org/10.1007/s40120-024-00682-xMyasthenia gravisBurden of diseaseMGC scoreFVCRefractory patientsMGQoL15 |
| spellingShingle | Stanislav Voháňka Aleš Tichopád Magda Horáková Jana Junkerová Michala Jakubíková Jiří Piťha Michaela Týblová Daniela Vlažná Katarína Breciková Jacek Cudny Petr Hájek Burden of Myasthenia Gravis in the Czech Republic: Analysis of the Nationwide Patient Registry Neurology and Therapy Myasthenia gravis Burden of disease MGC score FVC Refractory patients MGQoL15 |
| title | Burden of Myasthenia Gravis in the Czech Republic: Analysis of the Nationwide Patient Registry |
| title_full | Burden of Myasthenia Gravis in the Czech Republic: Analysis of the Nationwide Patient Registry |
| title_fullStr | Burden of Myasthenia Gravis in the Czech Republic: Analysis of the Nationwide Patient Registry |
| title_full_unstemmed | Burden of Myasthenia Gravis in the Czech Republic: Analysis of the Nationwide Patient Registry |
| title_short | Burden of Myasthenia Gravis in the Czech Republic: Analysis of the Nationwide Patient Registry |
| title_sort | burden of myasthenia gravis in the czech republic analysis of the nationwide patient registry |
| topic | Myasthenia gravis Burden of disease MGC score FVC Refractory patients MGQoL15 |
| url | https://doi.org/10.1007/s40120-024-00682-x |
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