Biomaterial-based regenerative therapeutic strategies for spinal cord injury
Abstract As one of the most intractable neurological diseases, spinal cord injury (SCI) often leads to permanent neurological impairment in patients. Unfortunately, due to the complex pathological mechanisms and unique postinjury microenvironment, there is currently no way to completely repair the i...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | NPG Asia Materials |
| Online Access: | https://doi.org/10.1038/s41427-023-00526-4 |
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| _version_ | 1832594610501713920 |
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| author | Keyi Chen Wei Yu Genjiang Zheng Zeng Xu Chen Yang Yunhao Wang Zhihao Yue Weien Yuan Bo Hu Huajiang Chen |
| author_facet | Keyi Chen Wei Yu Genjiang Zheng Zeng Xu Chen Yang Yunhao Wang Zhihao Yue Weien Yuan Bo Hu Huajiang Chen |
| author_sort | Keyi Chen |
| collection | DOAJ |
| description | Abstract As one of the most intractable neurological diseases, spinal cord injury (SCI) often leads to permanent neurological impairment in patients. Unfortunately, due to the complex pathological mechanisms and unique postinjury microenvironment, there is currently no way to completely repair the injured spinal cord. In recent years, with the rapid development of tissue engineering technology, the combination of biomaterials and medicine has provided a new idea for treating SCI. Here, we systematically summarize representative biomaterials, including natural, synthetic, nano, and hybrid materials, and their applications in SCI treatment. In addition, we describe several state-of-the-art fabrication techniques for tissue engineering. Importantly, we provide novel insights for the use of biomaterial-based therapeutic strategies to reduce secondary damage and promote repair. Finally, we discuss several biomaterial clinical studies. This review aims to provide a reference and new insights for the future exploration of spinal cord regeneration strategies. |
| format | Article |
| id | doaj-art-38e89f521a7b45a498a6c1dd3988d52c |
| institution | Kabale University |
| issn | 1884-4057 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | NPG Asia Materials |
| spelling | doaj-art-38e89f521a7b45a498a6c1dd3988d52c2025-01-19T12:28:38ZengNature PortfolioNPG Asia Materials1884-40572024-01-0116112910.1038/s41427-023-00526-4Biomaterial-based regenerative therapeutic strategies for spinal cord injuryKeyi Chen0Wei Yu1Genjiang Zheng2Zeng Xu3Chen Yang4Yunhao Wang5Zhihao Yue6Weien Yuan7Bo Hu8Huajiang Chen9Spine Center, Department of Orthopedics, Changzheng Hospital, Naval Medical UniversityEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong UniversitySpine Center, Department of Orthopedics, Changzheng Hospital, Naval Medical UniversitySpine Center, Department of Orthopedics, Changzheng Hospital, Naval Medical UniversitySpine Center, Department of Orthopedics, Changzheng Hospital, Naval Medical UniversitySpine Center, Department of Orthopedics, Changzheng Hospital, Naval Medical UniversitySpine Center, Department of Orthopedics, Changzheng Hospital, Naval Medical UniversityEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong UniversitySpine Center, Department of Orthopedics, Changzheng Hospital, Naval Medical UniversitySpine Center, Department of Orthopedics, Changzheng Hospital, Naval Medical UniversityAbstract As one of the most intractable neurological diseases, spinal cord injury (SCI) often leads to permanent neurological impairment in patients. Unfortunately, due to the complex pathological mechanisms and unique postinjury microenvironment, there is currently no way to completely repair the injured spinal cord. In recent years, with the rapid development of tissue engineering technology, the combination of biomaterials and medicine has provided a new idea for treating SCI. Here, we systematically summarize representative biomaterials, including natural, synthetic, nano, and hybrid materials, and their applications in SCI treatment. In addition, we describe several state-of-the-art fabrication techniques for tissue engineering. Importantly, we provide novel insights for the use of biomaterial-based therapeutic strategies to reduce secondary damage and promote repair. Finally, we discuss several biomaterial clinical studies. This review aims to provide a reference and new insights for the future exploration of spinal cord regeneration strategies.https://doi.org/10.1038/s41427-023-00526-4 |
| spellingShingle | Keyi Chen Wei Yu Genjiang Zheng Zeng Xu Chen Yang Yunhao Wang Zhihao Yue Weien Yuan Bo Hu Huajiang Chen Biomaterial-based regenerative therapeutic strategies for spinal cord injury NPG Asia Materials |
| title | Biomaterial-based regenerative therapeutic strategies for spinal cord injury |
| title_full | Biomaterial-based regenerative therapeutic strategies for spinal cord injury |
| title_fullStr | Biomaterial-based regenerative therapeutic strategies for spinal cord injury |
| title_full_unstemmed | Biomaterial-based regenerative therapeutic strategies for spinal cord injury |
| title_short | Biomaterial-based regenerative therapeutic strategies for spinal cord injury |
| title_sort | biomaterial based regenerative therapeutic strategies for spinal cord injury |
| url | https://doi.org/10.1038/s41427-023-00526-4 |
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