Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models
Follicular helper CD4+ T (TFH) cells play a fundamental role in humoral immunity deriving from their ability to provide help for germinal center (GC) formation, B cell differentiation into plasma cells and memory cells, and antibody production in secondary lymphoid tissues. TFH cells can be identifi...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/638968 |
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| author | Xueli Fan Chenhong Lin Jinming Han Xinmei Jiang Jie Zhu Tao Jin |
| author_facet | Xueli Fan Chenhong Lin Jinming Han Xinmei Jiang Jie Zhu Tao Jin |
| author_sort | Xueli Fan |
| collection | DOAJ |
| description | Follicular helper CD4+ T (TFH) cells play a fundamental role in humoral immunity deriving from their ability to provide help for germinal center (GC) formation, B cell differentiation into plasma cells and memory cells, and antibody production in secondary lymphoid tissues. TFH cells can be identified by a combination of markers, including the chemokine receptor CXCR5, costimulatory molecules ICOS and PD-1, transcription repressor Bcl-6, and cytokine IL-21. It is difficult and impossible to get access to secondary lymphoid tissues in humans, so studies are usually performed with human peripheral blood samples as circulating counterparts of tissue TFH cells. A balance of TFH cell generation and function is critical for protective antibody response, whereas overactivation of TFH cells or overexpression of TFH-associated molecules may result in autoimmune diseases. Emerging data have shown that TFH cells and TFH-associated molecules may be involved in the pathogenesis of neuroautoimmune diseases including multiple sclerosis (MS), neuromyelitis optica (NMO)/neuromyelitis optica spectrum disorders (NMOSD), and myasthenia gravis (MG). This review summarizes the features of TFH cells, including their development, function, and roles as well as TFH-associated molecules in neuroautoimmune diseases and their animal models. |
| format | Article |
| id | doaj-art-38e734fb25ff4324b5661e92ece99fc0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-38e734fb25ff4324b5661e92ece99fc02025-02-03T01:32:58ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/638968638968Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal ModelsXueli Fan0Chenhong Lin1Jinming Han2Xinmei Jiang3Jie Zhu4Tao Jin5Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun 130021, ChinaDepartment of Neurology, The First Hospital of Jilin University, Jilin University, Changchun 130021, ChinaDepartment of Neurology, The First Hospital of Jilin University, Jilin University, Changchun 130021, ChinaDepartment of Neurology, The First Hospital of Jilin University, Jilin University, Changchun 130021, ChinaDepartment of Neurology, The First Hospital of Jilin University, Jilin University, Changchun 130021, ChinaDepartment of Neurology, The First Hospital of Jilin University, Jilin University, Changchun 130021, ChinaFollicular helper CD4+ T (TFH) cells play a fundamental role in humoral immunity deriving from their ability to provide help for germinal center (GC) formation, B cell differentiation into plasma cells and memory cells, and antibody production in secondary lymphoid tissues. TFH cells can be identified by a combination of markers, including the chemokine receptor CXCR5, costimulatory molecules ICOS and PD-1, transcription repressor Bcl-6, and cytokine IL-21. It is difficult and impossible to get access to secondary lymphoid tissues in humans, so studies are usually performed with human peripheral blood samples as circulating counterparts of tissue TFH cells. A balance of TFH cell generation and function is critical for protective antibody response, whereas overactivation of TFH cells or overexpression of TFH-associated molecules may result in autoimmune diseases. Emerging data have shown that TFH cells and TFH-associated molecules may be involved in the pathogenesis of neuroautoimmune diseases including multiple sclerosis (MS), neuromyelitis optica (NMO)/neuromyelitis optica spectrum disorders (NMOSD), and myasthenia gravis (MG). This review summarizes the features of TFH cells, including their development, function, and roles as well as TFH-associated molecules in neuroautoimmune diseases and their animal models.http://dx.doi.org/10.1155/2015/638968 |
| spellingShingle | Xueli Fan Chenhong Lin Jinming Han Xinmei Jiang Jie Zhu Tao Jin Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models Mediators of Inflammation |
| title | Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models |
| title_full | Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models |
| title_fullStr | Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models |
| title_full_unstemmed | Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models |
| title_short | Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models |
| title_sort | follicular helper cd4 t cells in human neuroautoimmune diseases and their animal models |
| url | http://dx.doi.org/10.1155/2015/638968 |
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