Identification of m6A-modified gene signatures in lung adenocarcinoma tumorigenesis and their potential role in drug resistance

Identification of m6A-modified gene signatures in lung adenocarcinoma tumorigenesis and their potential role in drug resistance

Abstract Background Lung cancer is one of the most commonly diagnosed cancers. N 6-methyladenosine (m6A) modification has a profound impact on RNA translation, splicing, transportation, and stability. Aims This research aimed to identify and verify m6A-modified signatures for Lung adenocarcinoma (LU...

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Bibliographic Details
Main Authors: Xiaomin Han, Qiang Ma, Ruyi Chang, Siyuan Xin, Guojun Zhang, Ruilong Wang, Yukun Wang
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Discover Oncology
Subjects:
LUAD tumorigenesis
LASSO
WGCNA
Pearson correlation coefficient
m6A-seq
Drug resistance
Online Access:https://doi.org/10.1007/s12672-025-02106-0
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