Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR Heterodimerization
GPR43, a G-protein coupled receptor recognizing short-chain fatty acids, has been reported to participate in many biological functions of white adipocytes, such as adipogenesis and lipolysis. However, the functional role of GPR43 in brown adipocytes is still not clear. In this study, we investigated...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2018/1051074 |
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| _version_ | 1832562314099818496 |
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| author | Jiamiao Hu Arong Zhou Peter C. K. Cheung Baodong Zheng Shaoxiao Zeng Shaoling Lin |
| author_facet | Jiamiao Hu Arong Zhou Peter C. K. Cheung Baodong Zheng Shaoxiao Zeng Shaoling Lin |
| author_sort | Jiamiao Hu |
| collection | DOAJ |
| description | GPR43, a G-protein coupled receptor recognizing short-chain fatty acids, has been reported to participate in many biological functions of white adipocytes, such as adipogenesis and lipolysis. However, the functional role of GPR43 in brown adipocytes is still not clear. In this study, we investigated the effects of the PPARγ agonist rosiglitazone on GPR43 expression in brown adipogenesis. The results demonstrated that GPR43 was expressed during the late phase of brown adipocyte differentiation, which could be further augmented by adipogenic agent rosiglitazone treatment. The PPARγ/RXR heterodimerization was found to be the key transcription factor for this enhancing effect of rosiglitazone on GPR43 expression. Taken together, these results suggested GPR43 levels might be regulated by PPARγ-activated events during brown adipocytes differentiation and reflect the adipogenesis status of brown adipocytes. |
| format | Article |
| id | doaj-art-38e46b6325424e98aab149e753e37ede |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-38e46b6325424e98aab149e753e37ede2025-02-03T01:22:55ZengWileyPPAR Research1687-47571687-47652018-01-01201810.1155/2018/10510741051074Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR HeterodimerizationJiamiao Hu0Arong Zhou1Peter C. K. Cheung2Baodong Zheng3Shaoxiao Zeng4Shaoling Lin5College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong KongCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaGPR43, a G-protein coupled receptor recognizing short-chain fatty acids, has been reported to participate in many biological functions of white adipocytes, such as adipogenesis and lipolysis. However, the functional role of GPR43 in brown adipocytes is still not clear. In this study, we investigated the effects of the PPARγ agonist rosiglitazone on GPR43 expression in brown adipogenesis. The results demonstrated that GPR43 was expressed during the late phase of brown adipocyte differentiation, which could be further augmented by adipogenic agent rosiglitazone treatment. The PPARγ/RXR heterodimerization was found to be the key transcription factor for this enhancing effect of rosiglitazone on GPR43 expression. Taken together, these results suggested GPR43 levels might be regulated by PPARγ-activated events during brown adipocytes differentiation and reflect the adipogenesis status of brown adipocytes.http://dx.doi.org/10.1155/2018/1051074 |
| spellingShingle | Jiamiao Hu Arong Zhou Peter C. K. Cheung Baodong Zheng Shaoxiao Zeng Shaoling Lin Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR Heterodimerization PPAR Research |
| title | Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR Heterodimerization |
| title_full | Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR Heterodimerization |
| title_fullStr | Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR Heterodimerization |
| title_full_unstemmed | Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR Heterodimerization |
| title_short | Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR Heterodimerization |
| title_sort | expression of gpr43 in brown adipogenesis is enhanced by rosiglitazone and controlled by pparγ rxr heterodimerization |
| url | http://dx.doi.org/10.1155/2018/1051074 |
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