Antibody responses against influenza A decline with successive years of annual influenza vaccination
Abstract Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020–2021. Sera were collected pre-vaccination and ~14 and ~180 days p...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-024-01057-x |
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| author | Sheena G. Sullivan Arseniy Khvorov Louise Carolan Leslie Dowson A. Jessica Hadiprodjo Stephany Sánchez-Ovando Yi Liu Vivian K. Y. Leung David Hodgson Christopher C. Blyth Marion Macnish Allen C. Cheng Michelle Haugenauer Julia Clark Sonia Dougherty Kristine Macartney Archana Koirala Ameneh Khatami Ajay Jadhav Helen Marshall Kathryn E. Riley Peter A. B. Wark Catherine Delahunty Kanta Subbarao Adam J. Kucharski Annette Fox |
| author_facet | Sheena G. Sullivan Arseniy Khvorov Louise Carolan Leslie Dowson A. Jessica Hadiprodjo Stephany Sánchez-Ovando Yi Liu Vivian K. Y. Leung David Hodgson Christopher C. Blyth Marion Macnish Allen C. Cheng Michelle Haugenauer Julia Clark Sonia Dougherty Kristine Macartney Archana Koirala Ameneh Khatami Ajay Jadhav Helen Marshall Kathryn E. Riley Peter A. B. Wark Catherine Delahunty Kanta Subbarao Adam J. Kucharski Annette Fox |
| author_sort | Sheena G. Sullivan |
| collection | DOAJ |
| description | Abstract Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020–2021. Sera were collected pre-vaccination and ~14 and ~180 days post-vaccination and assessed in haemagglutination inhibition assay against egg-grown vaccine and equivalent cell-grown viruses. Responses to vaccination were compared by the number of prior vaccinations. Baseline sera were available for 595 HCW in 2020 and 1031 in 2021. 5% had not been vaccinated during five years prior to enrolment and 55% had been vaccinated every year. Post-vaccination titres for all vaccine antigens were lowest among HCW vaccinated in all 5-prior years and highest among HCW with 0 or 1 prior vaccinations, even after adjustment. This was observed for both influenza A subtypes and was dependent on pre-vaccination titre. Expanded cohorts are needed to better understand how this translates to vaccine effectiveness. |
| format | Article |
| id | doaj-art-38e429ba76dc440b89388a1c53127896 |
| institution | Kabale University |
| issn | 2059-0105 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj-art-38e429ba76dc440b89388a1c531278962025-01-19T12:09:16ZengNature Portfolionpj Vaccines2059-01052025-01-0110111010.1038/s41541-024-01057-xAntibody responses against influenza A decline with successive years of annual influenza vaccinationSheena G. Sullivan0Arseniy Khvorov1Louise Carolan2Leslie Dowson3A. Jessica Hadiprodjo4Stephany Sánchez-Ovando5Yi Liu6Vivian K. Y. Leung7David Hodgson8Christopher C. Blyth9Marion Macnish10Allen C. Cheng11Michelle Haugenauer12Julia Clark13Sonia Dougherty14Kristine Macartney15Archana Koirala16Ameneh Khatami17Ajay Jadhav18Helen Marshall19Kathryn E. Riley20Peter A. B. Wark21Catherine Delahunty22Kanta Subbarao23Adam J. Kucharski24Annette Fox25WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and ImmunityWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and ImmunityWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and ImmunityDepartment of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and ImmunityWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and ImmunityWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and ImmunityWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and ImmunityDepartment of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and ImmunityDepartment of Infectious Disease Epidemiology and Dynamics, London School of Hygiene and Tropical MedicineWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids InstituteWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids InstituteSchool of Clinical Sciences, Monash UniversityAlfred HealthQueensland Children’s HospitalQueensland Children’s HospitalThe Children’s Hospital at WestmeadThe Children’s Hospital at WestmeadThe Children’s Hospital at WestmeadThe Children’s Hospital at WestmeadThe Women and Children’s Health NetworkThe Women and Children’s Health NetworkJohn Hunter HospitalJohn Hunter HospitalWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and ImmunityDepartment of Infectious Disease Epidemiology and Dynamics, London School of Hygiene and Tropical MedicineWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and ImmunityAbstract Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020–2021. Sera were collected pre-vaccination and ~14 and ~180 days post-vaccination and assessed in haemagglutination inhibition assay against egg-grown vaccine and equivalent cell-grown viruses. Responses to vaccination were compared by the number of prior vaccinations. Baseline sera were available for 595 HCW in 2020 and 1031 in 2021. 5% had not been vaccinated during five years prior to enrolment and 55% had been vaccinated every year. Post-vaccination titres for all vaccine antigens were lowest among HCW vaccinated in all 5-prior years and highest among HCW with 0 or 1 prior vaccinations, even after adjustment. This was observed for both influenza A subtypes and was dependent on pre-vaccination titre. Expanded cohorts are needed to better understand how this translates to vaccine effectiveness.https://doi.org/10.1038/s41541-024-01057-x |
| spellingShingle | Sheena G. Sullivan Arseniy Khvorov Louise Carolan Leslie Dowson A. Jessica Hadiprodjo Stephany Sánchez-Ovando Yi Liu Vivian K. Y. Leung David Hodgson Christopher C. Blyth Marion Macnish Allen C. Cheng Michelle Haugenauer Julia Clark Sonia Dougherty Kristine Macartney Archana Koirala Ameneh Khatami Ajay Jadhav Helen Marshall Kathryn E. Riley Peter A. B. Wark Catherine Delahunty Kanta Subbarao Adam J. Kucharski Annette Fox Antibody responses against influenza A decline with successive years of annual influenza vaccination npj Vaccines |
| title | Antibody responses against influenza A decline with successive years of annual influenza vaccination |
| title_full | Antibody responses against influenza A decline with successive years of annual influenza vaccination |
| title_fullStr | Antibody responses against influenza A decline with successive years of annual influenza vaccination |
| title_full_unstemmed | Antibody responses against influenza A decline with successive years of annual influenza vaccination |
| title_short | Antibody responses against influenza A decline with successive years of annual influenza vaccination |
| title_sort | antibody responses against influenza a decline with successive years of annual influenza vaccination |
| url | https://doi.org/10.1038/s41541-024-01057-x |
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