The Benefits and Risks of Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma: Prospective Cohort Study
Objectives. This study evaluated the benefits of performing prophylactic central neck dissection (CND) with total thyroidectomy (TT) in management of papillary thyroid carcinoma (PTC) patients who were clinically node-negative at presentation. Methods. A total of 257 patients with stage T1 or T2 PTC...
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| Format: | Article |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/571480 |
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| author | Doh Young Lee Kyoung Ho Oh Jae-Gu Cho Soon-Young Kwon Jeong-Soo Woo Seung-Kuk Baek Kwang-Yoon Jung |
| author_facet | Doh Young Lee Kyoung Ho Oh Jae-Gu Cho Soon-Young Kwon Jeong-Soo Woo Seung-Kuk Baek Kwang-Yoon Jung |
| author_sort | Doh Young Lee |
| collection | DOAJ |
| description | Objectives. This study evaluated the benefits of performing prophylactic central neck dissection (CND) with total thyroidectomy (TT) in management of papillary thyroid carcinoma (PTC) patients who were clinically node-negative at presentation. Methods. A total of 257 patients with stage T1 or T2 PTC and without preoperative evidence of lymph node involvement (N0) were enrolled in this prospective study. The patients were randomly assigned to two groups: (1) a total thyroidectomy (TT) group (n=104) or (2) a TT plus CND group (n=153). The two groups were compared for their perioperative data, complication rates, disease recurrence rates, and clinical outcomes. Results. The two groups of patients were similar in age, sex ratio, follow-up duration, and tumor size (P=0.227, 0.359, 0.214, and 0.878, resp.). The two groups showed similar rates of disease recurrence (3.9% in the TT group versus 3.3% in the TT plus CND group); however, complications occurred more frequently in the TT plus CND group; especially transient hypocalcemia (P=0.043). Conclusions. Patients treated with TT plus CND had a higher rate of complications with similar recurrence rate. We believe that CND may not be routinely recommended when treating patients with PTC. |
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| id | doaj-art-38e241e4c64842f684af8301777e7471 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-38e241e4c64842f684af8301777e74712025-02-03T05:45:12ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/571480571480The Benefits and Risks of Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma: Prospective Cohort StudyDoh Young Lee0Kyoung Ho Oh1Jae-Gu Cho2Soon-Young Kwon3Jeong-Soo Woo4Seung-Kuk Baek5Kwang-Yoon Jung6Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul 136-705, Republic of KoreaObjectives. This study evaluated the benefits of performing prophylactic central neck dissection (CND) with total thyroidectomy (TT) in management of papillary thyroid carcinoma (PTC) patients who were clinically node-negative at presentation. Methods. A total of 257 patients with stage T1 or T2 PTC and without preoperative evidence of lymph node involvement (N0) were enrolled in this prospective study. The patients were randomly assigned to two groups: (1) a total thyroidectomy (TT) group (n=104) or (2) a TT plus CND group (n=153). The two groups were compared for their perioperative data, complication rates, disease recurrence rates, and clinical outcomes. Results. The two groups of patients were similar in age, sex ratio, follow-up duration, and tumor size (P=0.227, 0.359, 0.214, and 0.878, resp.). The two groups showed similar rates of disease recurrence (3.9% in the TT group versus 3.3% in the TT plus CND group); however, complications occurred more frequently in the TT plus CND group; especially transient hypocalcemia (P=0.043). Conclusions. Patients treated with TT plus CND had a higher rate of complications with similar recurrence rate. We believe that CND may not be routinely recommended when treating patients with PTC.http://dx.doi.org/10.1155/2015/571480 |
| spellingShingle | Doh Young Lee Kyoung Ho Oh Jae-Gu Cho Soon-Young Kwon Jeong-Soo Woo Seung-Kuk Baek Kwang-Yoon Jung The Benefits and Risks of Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma: Prospective Cohort Study International Journal of Endocrinology |
| title | The Benefits and Risks of Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma: Prospective Cohort Study |
| title_full | The Benefits and Risks of Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma: Prospective Cohort Study |
| title_fullStr | The Benefits and Risks of Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma: Prospective Cohort Study |
| title_full_unstemmed | The Benefits and Risks of Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma: Prospective Cohort Study |
| title_short | The Benefits and Risks of Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma: Prospective Cohort Study |
| title_sort | benefits and risks of prophylactic central neck dissection for papillary thyroid carcinoma prospective cohort study |
| url | http://dx.doi.org/10.1155/2015/571480 |
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