Research Progress on the Antibacterial Activity of Natural Flavonoids
The use of antibiotics has greatly improved the treatment of bacterial infections; however, its abuse and misuse has led to a rapid rise in multidrug-resistant (MDR) bacteria. Therefore, the search for new antimicrobial strategies has become critical. Natural flavonoids, a class of widely existing p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/4/334 |
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| author | Zhijin Zhang Mingze Cao Zixuan Shang Jing Xu Xu Chen Zhen Zhu Weiwei Wang Xiaojuan Wei Xuzheng Zhou Yubin Bai Jiyu Zhang |
| author_facet | Zhijin Zhang Mingze Cao Zixuan Shang Jing Xu Xu Chen Zhen Zhu Weiwei Wang Xiaojuan Wei Xuzheng Zhou Yubin Bai Jiyu Zhang |
| author_sort | Zhijin Zhang |
| collection | DOAJ |
| description | The use of antibiotics has greatly improved the treatment of bacterial infections; however, its abuse and misuse has led to a rapid rise in multidrug-resistant (MDR) bacteria. Therefore, the search for new antimicrobial strategies has become critical. Natural flavonoids, a class of widely existing phytochemicals, have gained significant research interest for their diverse biological activities and antibacterial effects on various drug-resistant bacteria. This review summarizes the latest research progress on flavonoids, with a particular focus on several flavonoids exhibiting certain antibacterial activity, and explores their antibacterial mechanisms, including disruption of cell membranes and cell walls, inhibition of proteins and nucleic acids, interference with signal transduction, suppression of efflux pump activity, and inhibition of biofilm formation and virulence factor production. Additionally, we have reviewed the synergistic combinations of flavonoids with antibiotics, such as the combination of quercetin with colistin or EGCG with tetracycline, which significantly enhance therapeutic efficacy. |
| format | Article |
| id | doaj-art-38e205d20c8f415dbedc4514dc89be21 |
| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-38e205d20c8f415dbedc4514dc89be212025-08-20T02:28:40ZengMDPI AGAntibiotics2079-63822025-03-0114433410.3390/antibiotics14040334Research Progress on the Antibacterial Activity of Natural FlavonoidsZhijin Zhang0Mingze Cao1Zixuan Shang2Jing Xu3Xu Chen4Zhen Zhu5Weiwei Wang6Xiaojuan Wei7Xuzheng Zhou8Yubin Bai9Jiyu Zhang10Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, ChinaCollege of Life Science and Food Engineering, Hebei University of Engineering, Congtai District, Handan 056038, ChinaKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, ChinaKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, ChinaKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, ChinaCollege of Life Science and Food Engineering, Hebei University of Engineering, Congtai District, Handan 056038, ChinaKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, ChinaKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, ChinaKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, ChinaKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, ChinaKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, ChinaThe use of antibiotics has greatly improved the treatment of bacterial infections; however, its abuse and misuse has led to a rapid rise in multidrug-resistant (MDR) bacteria. Therefore, the search for new antimicrobial strategies has become critical. Natural flavonoids, a class of widely existing phytochemicals, have gained significant research interest for their diverse biological activities and antibacterial effects on various drug-resistant bacteria. This review summarizes the latest research progress on flavonoids, with a particular focus on several flavonoids exhibiting certain antibacterial activity, and explores their antibacterial mechanisms, including disruption of cell membranes and cell walls, inhibition of proteins and nucleic acids, interference with signal transduction, suppression of efflux pump activity, and inhibition of biofilm formation and virulence factor production. Additionally, we have reviewed the synergistic combinations of flavonoids with antibiotics, such as the combination of quercetin with colistin or EGCG with tetracycline, which significantly enhance therapeutic efficacy.https://www.mdpi.com/2079-6382/14/4/334natural flavonoidsmultidrug-resistant bacteriaantibacterial activityantibacterial mechanismsynergistic effects |
| spellingShingle | Zhijin Zhang Mingze Cao Zixuan Shang Jing Xu Xu Chen Zhen Zhu Weiwei Wang Xiaojuan Wei Xuzheng Zhou Yubin Bai Jiyu Zhang Research Progress on the Antibacterial Activity of Natural Flavonoids Antibiotics natural flavonoids multidrug-resistant bacteria antibacterial activity antibacterial mechanism synergistic effects |
| title | Research Progress on the Antibacterial Activity of Natural Flavonoids |
| title_full | Research Progress on the Antibacterial Activity of Natural Flavonoids |
| title_fullStr | Research Progress on the Antibacterial Activity of Natural Flavonoids |
| title_full_unstemmed | Research Progress on the Antibacterial Activity of Natural Flavonoids |
| title_short | Research Progress on the Antibacterial Activity of Natural Flavonoids |
| title_sort | research progress on the antibacterial activity of natural flavonoids |
| topic | natural flavonoids multidrug-resistant bacteria antibacterial activity antibacterial mechanism synergistic effects |
| url | https://www.mdpi.com/2079-6382/14/4/334 |
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