The Contractile Function of Ventricular Cardiomyocytes Is More Sensitive to Acute 17β-Estradiol Treatment Compared to Atrial Cardiomyocytes

The Contractile Function of Ventricular Cardiomyocytes Is More Sensitive to Acute 17β-Estradiol Treatment Compared to Atrial Cardiomyocytes

17β-estradiol (E2) is the most active metabolite of estrogen with a wide range of physiological action on cardiac muscle. Previous studies have reported E2 effects predominantly for the ventricles, while the E2 impact on the atria has been less examined. In this study, we focused on the direct E2 ef...

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Bibliographic Details
Main Authors: Tatiana A. Myachina, Xenia A. Butova, Raisa A. Simonova, Denis A. Volzhaninov, Anastasia M. Kochurova, Galina V. Kopylova, Daniil V. Shchepkin, Anastasia D. Khokhlova
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
17β-estradiol
atria
ventricles
single cardiomyocyte
sarcomere shortening-relengthening
tension–length relationship
Online Access:https://www.mdpi.com/2073-4409/14/8/561
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