B Cells in Autoimmune Diseases
The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal centers...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.6064/2012/215308 |
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| _version_ | 1832563210589306880 |
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| author | Christiane S. Hampe |
| author_facet | Christiane S. Hampe |
| author_sort | Christiane S. Hampe |
| collection | DOAJ |
| description | The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal centers. Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated. This new understanding of the role of B cells opened up novel therapeutic options for the treatment of autoimmune diseases. This paper includes an overview of the different functions of B cells in autoimmunity; the involvement of B cells in systemic lupus erythematosus, rheumatoid arthritis, and type 1 diabetes; and current B-cell-based therapeutic treatments. We conclude with a discussion of novel therapies aimed at the selective targeting of pathogenic B cells. |
| format | Article |
| id | doaj-art-38d5f2adc6f94078a31b121bd8fcda69 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-38d5f2adc6f94078a31b121bd8fcda692025-02-03T01:20:43ZengWileyScientifica2090-908X2012-01-01201210.6064/2012/215308215308B Cells in Autoimmune DiseasesChristiane S. Hampe0Department of Medicine, University of Washington, SLU-276, 850 Republican, Seattle, WA 98109, USAThe role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal centers. Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated. This new understanding of the role of B cells opened up novel therapeutic options for the treatment of autoimmune diseases. This paper includes an overview of the different functions of B cells in autoimmunity; the involvement of B cells in systemic lupus erythematosus, rheumatoid arthritis, and type 1 diabetes; and current B-cell-based therapeutic treatments. We conclude with a discussion of novel therapies aimed at the selective targeting of pathogenic B cells.http://dx.doi.org/10.6064/2012/215308 |
| spellingShingle | Christiane S. Hampe B Cells in Autoimmune Diseases Scientifica |
| title | B Cells in Autoimmune Diseases |
| title_full | B Cells in Autoimmune Diseases |
| title_fullStr | B Cells in Autoimmune Diseases |
| title_full_unstemmed | B Cells in Autoimmune Diseases |
| title_short | B Cells in Autoimmune Diseases |
| title_sort | b cells in autoimmune diseases |
| url | http://dx.doi.org/10.6064/2012/215308 |
| work_keys_str_mv | AT christianeshampe bcellsinautoimmunediseases |