Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease
Tau hyperphosphorylation is a typical pathological change in Alzheimer’s disease (AD) and is involved in the early onset and progression of AD. Epigenetic modification refers to heritable alterations in gene expression that are not caused by direct changes in the DNA sequence of the gene. Epigenetic...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/6856327 |
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| _version_ | 1832561967381872640 |
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| author | Chao-Chao Yu Tao Jiang Ao-Fei Yang Yan-Jun Du Miao Wu Li-Hong Kong |
| author_facet | Chao-Chao Yu Tao Jiang Ao-Fei Yang Yan-Jun Du Miao Wu Li-Hong Kong |
| author_sort | Chao-Chao Yu |
| collection | DOAJ |
| description | Tau hyperphosphorylation is a typical pathological change in Alzheimer’s disease (AD) and is involved in the early onset and progression of AD. Epigenetic modification refers to heritable alterations in gene expression that are not caused by direct changes in the DNA sequence of the gene. Epigenetic modifications, such as noncoding RNA regulation, DNA methylation, and histone modification, can directly or indirectly affect the regulation of tau phosphorylation, thereby participating in AD development and progression. This review summarizes the current research progress on the mechanisms of epigenetic modification associated with tau phosphorylation. |
| format | Article |
| id | doaj-art-38d2478d81e84841afd5d466d77cce58 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-38d2478d81e84841afd5d466d77cce582025-02-03T01:23:45ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/68563276856327Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s DiseaseChao-Chao Yu0Tao Jiang1Ao-Fei Yang2Yan-Jun Du3Miao Wu4Li-Hong Kong5Hubei University of Chinese Medicine, Wuhan, Hubei, ChinaHubei University of Chinese Medicine, Wuhan, Hubei, ChinaHubei Provincial Hospital of TCM, Wuhan, Hubei, ChinaHubei University of Chinese Medicine, Wuhan, Hubei, ChinaHubei Provincial Hospital of TCM, Wuhan, Hubei, ChinaHubei University of Chinese Medicine, Wuhan, Hubei, ChinaTau hyperphosphorylation is a typical pathological change in Alzheimer’s disease (AD) and is involved in the early onset and progression of AD. Epigenetic modification refers to heritable alterations in gene expression that are not caused by direct changes in the DNA sequence of the gene. Epigenetic modifications, such as noncoding RNA regulation, DNA methylation, and histone modification, can directly or indirectly affect the regulation of tau phosphorylation, thereby participating in AD development and progression. This review summarizes the current research progress on the mechanisms of epigenetic modification associated with tau phosphorylation.http://dx.doi.org/10.1155/2019/6856327 |
| spellingShingle | Chao-Chao Yu Tao Jiang Ao-Fei Yang Yan-Jun Du Miao Wu Li-Hong Kong Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease Neural Plasticity |
| title | Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease |
| title_full | Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease |
| title_fullStr | Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease |
| title_full_unstemmed | Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease |
| title_short | Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease |
| title_sort | epigenetic modulation on tau phosphorylation in alzheimer s disease |
| url | http://dx.doi.org/10.1155/2019/6856327 |
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