Circadian rhythm and aryl hydrocarbon receptor crosstalk in bone marrow adipose tissue and implications in leukemia

Circadian rhythm and aryl hydrocarbon receptor crosstalk in bone marrow adipose tissue and implications in leukemia

Abstract Leukemic cells modulate the bone marrow microenvironment to enhance their survival. Lipolysis in bone marrow adipose tissue (BMAT) has emerged as a critical factor supporting leukemic cell survival, yet understanding its primary role in leukemia development remains limited. Fanconi anemia (...

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Bibliographic Details
Main Authors: Bihter Muratoğlu, Cansu Özdemir, Cemil Can Eylem, Tuba Reçber, Emirhan Nemutlu, İdil Yet, Duygu Uçkan-Çetinkaya
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Bone marrow adipose tissue
Circadian rhythm
AhR signaling
Multi-omics
AML
Fanconi anemia
Online Access:https://doi.org/10.1038/s41598-025-93169-0
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