A rare case of sickle cell disease with musculoskeletal manifestations and normal peripheral smear
Sickle cell anaemia causes significant mortality and morbidity, with a decrease of 25–30 years in the average life expectancy. Over time, sickle cell disease produces various musculoskeletal abnormalities as a result of chronic anaemia. Ischaemia and infarction are the common complications that may...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Clinical and Scientific Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jcsr.jcsr_73_21 |
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| Summary: | Sickle cell anaemia causes significant mortality and morbidity, with a decrease of 25–30 years in the average life expectancy. Over time, sickle cell disease produces various musculoskeletal abnormalities as a result of chronic anaemia. Ischaemia and infarction are the common complications that may have long-term effects on the growth of bone; both infection and infarction may occur in muscle and soft tissue alone, without involving bone. Vasoocclusion may occur in muscle and lead to inflammation, oedema and myonecrosis. Fluid collections, haematomas and fat necrosis may occur in the soft tissue. We report a case of an adult male presenting with musculoskeletal manifestations and normal peripheral smear. The patient was diagnosed to have sickle cell disease and was managed accordingly. |
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| ISSN: | 2277-5706 2277-8357 |