Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder
<italic>Goal:</italic> REM Sleep Behavior Disorder (RBD) is a REM parasomnia that is associated to high risk of developing α-synucleinopathies, as Parkinson's disease (PD) or dementia with Lewy bodies, over time. This study aims at investigating the presence of auto...
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IEEE
2024-01-01
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| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
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| Online Access: | https://ieeexplore.ieee.org/document/10521879/ |
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| author | Nicla Mandas Maximiliano Mollura Giulia Baldazzi Parisa Sattar Maria Mura Elisa Casaglia Michela Figorilli Laura Giorgetti Pietro Mattioli Francesco Calizzano Francesco Fama Dario Arnaldi Monica Puligheddu Danilo Pani Riccardo Barbieri |
| author_facet | Nicla Mandas Maximiliano Mollura Giulia Baldazzi Parisa Sattar Maria Mura Elisa Casaglia Michela Figorilli Laura Giorgetti Pietro Mattioli Francesco Calizzano Francesco Fama Dario Arnaldi Monica Puligheddu Danilo Pani Riccardo Barbieri |
| author_sort | Nicla Mandas |
| collection | DOAJ |
| description | <italic>Goal:</italic> REM Sleep Behavior Disorder (RBD) is a REM parasomnia that is associated to high risk of developing α-synucleinopathies, as Parkinson's disease (PD) or dementia with Lewy bodies, over time. This study aims at investigating the presence of autonomic dysfunctions in RBD subjects, with and without PD, by assessing their sleep structure and autonomous nervous system activity along the different sleep stages. <italic>Methods:</italic> To this aim, an innovative framework combining a sleep transition model, by Markov chains, with an instantaneous assessment of autonomic state dynamics by statistical modeling of heart rate variability (HRV) dynamics through a point-process approach, was introduced. <italic>Results:</italic> In general, RBD groups showed lower HRV than controls across all sleep stages, as well as higher probabilities of transitioning towards lighter sleep stages. Subjects also affected by PD present an even lower HRV, but better sleep continuity. <italic>Conclusions:</italic> RBD patients suffer from sleep fragmentation and overall autonomic dysfunction, mainly due to lower autonomic activation across all sleep stages. Coexistence of PD seems to improve sleep quality, possibly due to a sleep-related relief of their symptoms. |
| format | Article |
| id | doaj-art-38c29913440c47aba0be5a00237fae03 |
| institution | Kabale University |
| issn | 2644-1276 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj-art-38c29913440c47aba0be5a00237fae032025-01-29T00:01:32ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762024-01-01585986610.1109/OJEMB.2024.339755010521879Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior DisorderNicla Mandas0https://orcid.org/0000-0001-5204-592XMaximiliano Mollura1https://orcid.org/0000-0002-2248-8145Giulia Baldazzi2https://orcid.org/0000-0003-1275-4961Parisa Sattar3https://orcid.org/0000-0002-9461-0568Maria Mura4https://orcid.org/0009-0009-3806-0002Elisa Casaglia5https://orcid.org/0000-0001-8741-3382Michela Figorilli6https://orcid.org/0000-0002-1638-1384Laura Giorgetti7https://orcid.org/0009-0003-3344-1160Pietro Mattioli8https://orcid.org/0000-0003-2563-5830Francesco Calizzano9https://orcid.org/0009-0003-1257-7472Francesco Fama10https://orcid.org/0000-0002-9084-9037Dario Arnaldi11https://orcid.org/0000-0001-6823-6069Monica Puligheddu12https://orcid.org/0000-0002-6837-6608Danilo Pani13https://orcid.org/0000-0003-1924-0875Riccardo Barbieri14https://orcid.org/0000-0001-9381-3833Hadron Academy, Istituto Universitario di Studi Superiori, IUSS, Pavia, ItalyDepartment of Electronic, Information and Bioengineering, Politecnico di Milano, Milano, ItalyDepartment of Electrical and Electronic Engineering, University of Cagliari, Cagliari, ItalyDepartment of Electrical and Electronic Engineering, University of Cagliari, Cagliari, ItalyDepartment of Electrical and Electronic Engineering, University of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, ItalyDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, ItalyDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, ItalyDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, ItalyDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, ItalyDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, ItalyDepartment of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, ItalyDepartment of Electrical and Electronic Engineering, University of Cagliari, Cagliari, ItalyDepartment of Electronic, Information and Bioengineering, Politecnico di Milano, Milano, Italy<italic>Goal:</italic> REM Sleep Behavior Disorder (RBD) is a REM parasomnia that is associated to high risk of developing α-synucleinopathies, as Parkinson's disease (PD) or dementia with Lewy bodies, over time. This study aims at investigating the presence of autonomic dysfunctions in RBD subjects, with and without PD, by assessing their sleep structure and autonomous nervous system activity along the different sleep stages. <italic>Methods:</italic> To this aim, an innovative framework combining a sleep transition model, by Markov chains, with an instantaneous assessment of autonomic state dynamics by statistical modeling of heart rate variability (HRV) dynamics through a point-process approach, was introduced. <italic>Results:</italic> In general, RBD groups showed lower HRV than controls across all sleep stages, as well as higher probabilities of transitioning towards lighter sleep stages. Subjects also affected by PD present an even lower HRV, but better sleep continuity. <italic>Conclusions:</italic> RBD patients suffer from sleep fragmentation and overall autonomic dysfunction, mainly due to lower autonomic activation across all sleep stages. Coexistence of PD seems to improve sleep quality, possibly due to a sleep-related relief of their symptoms.https://ieeexplore.ieee.org/document/10521879/Autonomous nervous systemheart rate variability (HRV)Markov chainspoint processREM sleep behavior disorder |
| spellingShingle | Nicla Mandas Maximiliano Mollura Giulia Baldazzi Parisa Sattar Maria Mura Elisa Casaglia Michela Figorilli Laura Giorgetti Pietro Mattioli Francesco Calizzano Francesco Fama Dario Arnaldi Monica Puligheddu Danilo Pani Riccardo Barbieri Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder IEEE Open Journal of Engineering in Medicine and Biology Autonomous nervous system heart rate variability (HRV) Markov chains point process REM sleep behavior disorder |
| title | Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder |
| title_full | Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder |
| title_fullStr | Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder |
| title_full_unstemmed | Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder |
| title_short | Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder |
| title_sort | characterization of sleep structure and autonomic dysfunction in rem sleep behavior disorder |
| topic | Autonomous nervous system heart rate variability (HRV) Markov chains point process REM sleep behavior disorder |
| url | https://ieeexplore.ieee.org/document/10521879/ |
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