A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1
Neurofibromatosis type 1 (NF1), also called von Recklinghausen’s disease, is a multisystemic disease caused by an alteration of the NF1 gene, a tumor suppressor located on the long arm of chromosome 17 (17q11.2). Loss of the gene function, due to a point mutation, leads to an increase in cell prolif...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2015/375416 |
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| author | Yoko Yamamoto Ken Kodama Shigekazu Yokoyama Masashi Takeda Shintaro Michishita |
| author_facet | Yoko Yamamoto Ken Kodama Shigekazu Yokoyama Masashi Takeda Shintaro Michishita |
| author_sort | Yoko Yamamoto |
| collection | DOAJ |
| description | Neurofibromatosis type 1 (NF1), also called von Recklinghausen’s disease, is a multisystemic disease caused by an alteration of the NF1 gene, a tumor suppressor located on the long arm of chromosome 17 (17q11.2). Loss of the gene function, due to a point mutation, leads to an increase in cell proliferation and the development of several tumors. We report a 60-year-old female patient manifesting hypercalcemia due to hyperparathyroidism, a solitary fibrous tumor (SFT) of the pleura, multiple gastrointestinal stromal tumors (GISTs), and moyamoya disease associated with NF1. The SFT and GISTs were removed by staged operations. Then, hypercalcemia was successfully controlled after resection of the parathyroid adenoma. Based on a literature review, these combinations have never been reported, and the relevant literature is briefly discussed. |
| format | Article |
| id | doaj-art-38bf335e2f6b4cec8552ae90986b0f3b |
| institution | Kabale University |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-38bf335e2f6b4cec8552ae90986b0f3b2025-02-03T01:02:30ZengWileyCase Reports in Surgery2090-69002090-69192015-01-01201510.1155/2015/375416375416A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1Yoko Yamamoto0Ken Kodama1Shigekazu Yokoyama2Masashi Takeda3Shintaro Michishita4Department of Thoracic Surgery, Yao Municipal Hospital, Yao City, Osaka 581-0069, JapanDepartment of Thoracic Surgery, Yao Municipal Hospital, Yao City, Osaka 581-0069, JapanDepartment of Gastroenterological Surgery, Yao Municipal Hospital, Yao City, Osaka 581-0069, JapanDepartment of Pathology, Yao Municipal Hospital, Yao City, Osaka 581-0069, JapanDepartment of Breast and Endocrine Surgery, Osaka University, Osaka 565-0871, JapanNeurofibromatosis type 1 (NF1), also called von Recklinghausen’s disease, is a multisystemic disease caused by an alteration of the NF1 gene, a tumor suppressor located on the long arm of chromosome 17 (17q11.2). Loss of the gene function, due to a point mutation, leads to an increase in cell proliferation and the development of several tumors. We report a 60-year-old female patient manifesting hypercalcemia due to hyperparathyroidism, a solitary fibrous tumor (SFT) of the pleura, multiple gastrointestinal stromal tumors (GISTs), and moyamoya disease associated with NF1. The SFT and GISTs were removed by staged operations. Then, hypercalcemia was successfully controlled after resection of the parathyroid adenoma. Based on a literature review, these combinations have never been reported, and the relevant literature is briefly discussed.http://dx.doi.org/10.1155/2015/375416 |
| spellingShingle | Yoko Yamamoto Ken Kodama Shigekazu Yokoyama Masashi Takeda Shintaro Michishita A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1 Case Reports in Surgery |
| title | A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1 |
| title_full | A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1 |
| title_fullStr | A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1 |
| title_full_unstemmed | A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1 |
| title_short | A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1 |
| title_sort | pleural solitary fibrous tumor multiple gastrointestinal stromal tumors moyamoya disease and hyperparathyroidism in a patient associated with nf1 |
| url | http://dx.doi.org/10.1155/2015/375416 |
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