Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024

Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024

Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug suscept...

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Bibliographic Details
Main Authors: Emi Takashita, Hiroko Morita, Shiho Nagata, Seiichiro Fujisaki, Hideka Miura, Tatsuya Ikeda, Kenichi Komabayashi, Mika Sasaki, Yohei Matoba, Tomoko Takahashi, Naomi Ogawa, Katsumi Mizuta, Sueshi Ito, Noriko Kishida, Kazuya Nakamura, Masayuki Shirakura, Shinji Watanabe, Hideki Hasegawa
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2025-05-01
Series:Emerging Infectious Diseases
Subjects:
influenza virus
influenza
viruses
cap-dependent endonuclease inhibitor
baloxavir marboxil
baloxavir acid
Online Access:https://wwwnc.cdc.gov/eid/article/31/5/24-1123_article
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